The course of rheumatoid factor, cryoglobulin, and immunoglobulin serum levels in the studied patients after rituximab therapy
| . | Median value . | Decrease less than 25% or unchanged . | Decrease 25% or greater . | Normalization . | Notes . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Months | 0 | +3 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | — |
| RF IU/mL | 536 | 121 | 1374-150 | 1 of 14 | 2 of 14 | 9 of 14 | 9 of 14 | 4 of 14 | 3 of 14 | Negative in patients 3, 4, 14 (+3 and +6) and 2 (+3) |
| Cryoglobulins mg/dL | 1305 | 767 | 8194-150 | 1 of 13 | 4 of 13 | 9 of 13 | 8 of 13 | 3 of 13 | 1 of 13 | Negative in patients 4 (+3 and +6) and 1, 14 (+3) |
| IgM g/L | 3 | 1.6 | 1.74-150 | 3 of 15 | 5 of 15 | 12 of 15 | 10 of 15 | NA | NA | Decrease ≥ 25% in patients 3–9, 11, 13, 14 (+6) |
| IgG g/L | 8.4 | 7.7 | 7.2 | 12 of 15 | 12 of 15 | 2 of 15 | 3 of 15 | NA | NA | Decrease ≥ 25% in patients 3, 4 (+3 and +6) and 8 (+6) |
| IgA g/L | 1.2 | 0.8 | 0.8 | 10 of 15 | 10 of 15 | 5 of 15 | 5 of 15 | NA | NA | Decrease ≥ 25% in patients 3–6, 8 (+3 and +6) |
| . | Median value . | Decrease less than 25% or unchanged . | Decrease 25% or greater . | Normalization . | Notes . | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Months | 0 | +3 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | +1 to +5 | +6 | — |
| RF IU/mL | 536 | 121 | 1374-150 | 1 of 14 | 2 of 14 | 9 of 14 | 9 of 14 | 4 of 14 | 3 of 14 | Negative in patients 3, 4, 14 (+3 and +6) and 2 (+3) |
| Cryoglobulins mg/dL | 1305 | 767 | 8194-150 | 1 of 13 | 4 of 13 | 9 of 13 | 8 of 13 | 3 of 13 | 1 of 13 | Negative in patients 4 (+3 and +6) and 1, 14 (+3) |
| IgM g/L | 3 | 1.6 | 1.74-150 | 3 of 15 | 5 of 15 | 12 of 15 | 10 of 15 | NA | NA | Decrease ≥ 25% in patients 3–9, 11, 13, 14 (+6) |
| IgG g/L | 8.4 | 7.7 | 7.2 | 12 of 15 | 12 of 15 | 2 of 15 | 3 of 15 | NA | NA | Decrease ≥ 25% in patients 3, 4 (+3 and +6) and 8 (+6) |
| IgA g/L | 1.2 | 0.8 | 0.8 | 10 of 15 | 10 of 15 | 5 of 15 | 5 of 15 | NA | NA | Decrease ≥ 25% in patients 3–6, 8 (+3 and +6) |
Changes were evaluated with respect to the baseline value in any single patient.
RF indicates rheumatoid factor (positive if ≥ 20 IU/mL); and —, not applicable.
P ≤ .05.