Table 1. Spi-B stimulates pDC... | American Society of Hematology

Table 1.

Spi-B stimulates pDC development from CD34⁺CD38⁻ fetal liver cells

Experiment no.	% BDCA2⁺HLA-DR⁺			% CD123⁺45RA⁺
Experiment no.	GPF⁺	Spi-B⁺	ΔSpi-B⁺	GFP⁺	Spi-B⁺	ΔSpi-B⁺
1	6.14	8.23	4.47	5.67	8.05	5.25
2	5.12	9.89	7.51	7.36	11.45	7.46
3	7.15	8.04	5.63	9.24	13.98	10.19
4	10.28	14.54	12.18	14.19	24.03	23.71
5	8.59	17.64	12.31	16.29	21.75	14.88
6	15.22	17.76	14.04	ND	ND	ND

Experiment no.	% BDCA2⁺HLA-DR⁺			% CD123⁺45RA⁺
Experiment no.	GPF⁺	Spi-B⁺	ΔSpi-B⁺	GFP⁺	Spi-B⁺	ΔSpi-B⁺
1	6.14	8.23	4.47	5.67	8.05	5.25
2	5.12	9.89	7.51	7.36	11.45	7.46
3	7.15	8.04	5.63	9.24	13.98	10.19
4	10.28	14.54	12.18	14.19	24.03	23.71
5	8.59	17.64	12.31	16.29	21.75	14.88
6	15.22	17.76	14.04	ND	ND	ND

Statistical analysis on the percentages of pDCs developing from CD34⁺ progenitors in the S17 assay was performed using a paired 2-tailed Student t test. For BDCA2⁺HLA-DR⁺, P = .021 for GFP versus Spi-B, .554 for GFP versus ΔSpi-B, and .001 for Spi-B versus ΔSpi-B. For CD123⁺CD45RA⁺, P= .013 for GFP versus Spi-B, .427 for GFP versus ΔSpi-B, and .028 for Spi-B versus ΔSpi-B.

ND indicates not determined.

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