Table 1. Ag-specific mucosal IgA Ab... | American Society of Hematology

Table 1.

Ag-specific mucosal IgA Ab responses following nasal immunization with MIP-1α or MIP-1β and OVA^*

Vaccine	End-point titers of anti-OVA IgA Abs
Vaccine	Feces	Vaginal wash	Nasal wash
OVA only	≤2	≤2	≤2
MIP-1α plus OVA	76.8 ± 7.5^†	22.5 ± 3.2^†	9.2 ± 1.8^†
MIP-1β plus OVA	153.1 ± 25.3^†	60.8 ± 8.1^†	14.8 ± 1.6^†

Vaccine	End-point titers of anti-OVA IgA Abs
Vaccine	Feces	Vaginal wash	Nasal wash
OVA only	≤2	≤2	≤2
MIP-1α plus OVA	76.8 ± 7.5^†	22.5 ± 3.2^†	9.2 ± 1.8^†
MIP-1β plus OVA	153.1 ± 25.3^†	60.8 ± 8.1^†	14.8 ± 1.6^†

Groups of 5 C57BL/6 mice were nasally immunized on days 0, 7, and 14 with 75 μg OVA and 0.0 or 1.0 μg MIP-1α or MIP-1β. The data presented are the mean Ab titers ± SEMs of 3 separate experiments. ELISA determined the distribution of OVA-specific serum and fecal Ab titers on day 21.

†

Statistically significant differences (P < .05) of Ab titers of mice that received OVA alone.

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