Characteristics of 204 patients with non-Hodgkin lymphoma, including the association of initial plasma levels of tumor necrosis factor and its soluble receptors (p55 and p75) with other prognostic variables in 85 patients who provided samples available for enzyme-linked immunosorbent assay
| Characteristics . | No. and distribution of patients (%) . | TNF . | p55 . | p75 . |
|---|---|---|---|---|
| P* | ||||
| Sex | ns | ns | ns | |
| Female | 113 (55) | |||
| Male | 91 (45) | |||
| Age | ns | .02 | ns | |
| ≤60 years | 113 (55) | |||
| >60 years | 91 (45) | |||
| Performance status (ECOG) | .02 | .0001 | .001 | |
| <2 | 157 (77) | |||
| ≥2 | 47 (23) | |||
| B symptoms | <.0001 | .0001 | <.0001 | |
| Absent | 150 (74) | |||
| Present | 54 (26) | |||
| Ann Arbor stage | .01 | ns | .003 | |
| I, II | 55 (27) | |||
| III, IV | 149 (73) | |||
| Serum LDH | .0008 | .004 | <.0001 | |
| ≤1 × normal | 108 (53) | |||
| >1 × normal | 96 (47) | |||
| Serum β2-microglobulin | <.0001 | <.0001 | <.0001 | |
| ≤3.0 mg/L | 122 (63) | |||
| >3.0 mg/L | 73 (37) | |||
| Unknown | 9 | |||
| No of extranodal sites | .01 | ns | .002 | |
| <2 | 118 (58) | |||
| ≥2 | 86 (42) | |||
| Serum albumin level | .0002 | <.0001 | <.0001 | |
| ≤35 g/L | 31 (16) | |||
| >35 g/L | 164 (84) | |||
| Unknown | 9 | |||
| Serum C-reactive protein | .004 | .0001 | .0008 | |
| ≤6.0 mg/L | 76 (45) | |||
| >6.0 mg/L | 93 (55) | |||
| Unknown | 35 | |||
| Hemoglobin | .03 | .0001 | .001 | |
| ≤12 g/dL | 76 (38) | |||
| >12 g/dL | 125 (62) | |||
| Unknown | 3 | |||
| Bulky tumor (≥10 cm) | .02 | .004 | .003 | |
| Absent | 136 (67) | |||
| Present | 68 (33) | |||
| Histology | ||||
| Diffuse large B-cell | 104 (51) | ns | .001 | .02 |
| Follicular | 62 (30) | |||
| Other | ||||
| Lymphocytic/lymphoplasmocytoid | 11 (5.5) | |||
| Marginal zone | 6 (3.0) | |||
| Mantle cell | 16 (8.0) | |||
| Burkitt cell | 2 (1.0) | |||
| Peripheral T-cell lymphoma | 3 (1.5) | |||
| International Prognostic Index risk groups | .0004 | <.0001 | <.0001 | |
| Low/Intermediate low | 112 (55) | |||
| Intermediate high/high | 92 (45) | |||
| Characteristics . | No. and distribution of patients (%) . | TNF . | p55 . | p75 . |
|---|---|---|---|---|
| P* | ||||
| Sex | ns | ns | ns | |
| Female | 113 (55) | |||
| Male | 91 (45) | |||
| Age | ns | .02 | ns | |
| ≤60 years | 113 (55) | |||
| >60 years | 91 (45) | |||
| Performance status (ECOG) | .02 | .0001 | .001 | |
| <2 | 157 (77) | |||
| ≥2 | 47 (23) | |||
| B symptoms | <.0001 | .0001 | <.0001 | |
| Absent | 150 (74) | |||
| Present | 54 (26) | |||
| Ann Arbor stage | .01 | ns | .003 | |
| I, II | 55 (27) | |||
| III, IV | 149 (73) | |||
| Serum LDH | .0008 | .004 | <.0001 | |
| ≤1 × normal | 108 (53) | |||
| >1 × normal | 96 (47) | |||
| Serum β2-microglobulin | <.0001 | <.0001 | <.0001 | |
| ≤3.0 mg/L | 122 (63) | |||
| >3.0 mg/L | 73 (37) | |||
| Unknown | 9 | |||
| No of extranodal sites | .01 | ns | .002 | |
| <2 | 118 (58) | |||
| ≥2 | 86 (42) | |||
| Serum albumin level | .0002 | <.0001 | <.0001 | |
| ≤35 g/L | 31 (16) | |||
| >35 g/L | 164 (84) | |||
| Unknown | 9 | |||
| Serum C-reactive protein | .004 | .0001 | .0008 | |
| ≤6.0 mg/L | 76 (45) | |||
| >6.0 mg/L | 93 (55) | |||
| Unknown | 35 | |||
| Hemoglobin | .03 | .0001 | .001 | |
| ≤12 g/dL | 76 (38) | |||
| >12 g/dL | 125 (62) | |||
| Unknown | 3 | |||
| Bulky tumor (≥10 cm) | .02 | .004 | .003 | |
| Absent | 136 (67) | |||
| Present | 68 (33) | |||
| Histology | ||||
| Diffuse large B-cell | 104 (51) | ns | .001 | .02 |
| Follicular | 62 (30) | |||
| Other | ||||
| Lymphocytic/lymphoplasmocytoid | 11 (5.5) | |||
| Marginal zone | 6 (3.0) | |||
| Mantle cell | 16 (8.0) | |||
| Burkitt cell | 2 (1.0) | |||
| Peripheral T-cell lymphoma | 3 (1.5) | |||
| International Prognostic Index risk groups | .0004 | <.0001 | <.0001 | |
| Low/Intermediate low | 112 (55) | |||
| Intermediate high/high | 92 (45) | |||
The associations of the tumor necrosis factor (TNF) and its soluble receptor plasma levels with other variables were compared by Mann-Whitney U test.