Univariate analysis of prognostic factors
| Factor . | OS . | AML evolution . | ||
|---|---|---|---|---|
| RR (95% CI) . | P . | RR (95% CI) . | P . | |
| FAB | < .0001 | < .0001 | ||
| RA | 1.0 | 1.0 | ||
| RARS | 1.70 (0.82-3.530) | 2.08 (0.42-10.29) | ||
| RAEB | 3.72 (2.48-5.59) | 15.56 (6.57-36.85) | ||
| RAEBt | 5.03 (3.26-7.76) | 20.30 (8.41-48.98) | ||
| CMML | 2.49 (1.32-4.70) | 9.10 (3.01-27.45) | ||
| Age, older than 60 y | 1.95 (1.39-2.72) | < .0001 | 1.06 (0.69-1.61) | .7927 |
| Sex, female | 0.62 (0.45-0.86) | .0040 | 0.845 (0.55-1.29) | .4335 |
| Hb, per increase of 1 g/dL | 0.88 (0.83-0.94) | .0002 | 0.86 (0.78-0.94) | .0010 |
| Neutrophil, per increase of 100/μL | 1.00 (0.99-1.00) | .3502 | 1.00 (0.99-1.01) | .2487 |
| PB-Eos, per increase of 100/μL | 1.03 (0.97-1.09) | .3010 | 1.06 (0.97-1.17) | .2079 |
| PB-Bas, per increase of 100/μL | 1.15 (1.01-1.29) | .0286 | 1.09 (0.91-1.30) | .3398 |
| Plt, per increase of 104/μL | 1.00 (0.99-1.01) | .6903 | 1.00 (0.99-1.02) | .5058 |
| BM-Mbl, per increase of 1% | 1.03 (1.02-1.05) | < .0001 | 1.08 (1.06-1.10) | < .0001 |
| BM-Eos, per increase of 1% | 1.07 (1.02-1.11) | .0053 | 1.06 (0.99-1.11) | .0675 |
| BM-Bas, per increase of 1% | 1.19 (1.07-1.33) | .0014 | 1.35 (1.18-1.54) | < .0001 |
| Cytogenetics | < .0001 | < .0001 | ||
| Good | 1.0 | 1.0 | ||
| Intermediate | 1.57 (1.05-2.35) | 1.95 (1.16-3.26) | ||
| High | 4.62 (3.25-6.56) | 2.86 (1.76-4.63) | ||
| IPSS | < .0001 | < .0001 | ||
| Low | 1.0 | 1.0 | ||
| Intermediate-1 | 1.39 (0.76-2.52) | 4.10 (0.98-17.20) | ||
| Intermediate-2 | 3.87 (2.10-7.11) | 12.012 (2.87-50.42) | ||
| High | 4.54 (2.41-8.55) | 26.03 (6.19-109.39) | ||
| Factor . | OS . | AML evolution . | ||
|---|---|---|---|---|
| RR (95% CI) . | P . | RR (95% CI) . | P . | |
| FAB | < .0001 | < .0001 | ||
| RA | 1.0 | 1.0 | ||
| RARS | 1.70 (0.82-3.530) | 2.08 (0.42-10.29) | ||
| RAEB | 3.72 (2.48-5.59) | 15.56 (6.57-36.85) | ||
| RAEBt | 5.03 (3.26-7.76) | 20.30 (8.41-48.98) | ||
| CMML | 2.49 (1.32-4.70) | 9.10 (3.01-27.45) | ||
| Age, older than 60 y | 1.95 (1.39-2.72) | < .0001 | 1.06 (0.69-1.61) | .7927 |
| Sex, female | 0.62 (0.45-0.86) | .0040 | 0.845 (0.55-1.29) | .4335 |
| Hb, per increase of 1 g/dL | 0.88 (0.83-0.94) | .0002 | 0.86 (0.78-0.94) | .0010 |
| Neutrophil, per increase of 100/μL | 1.00 (0.99-1.00) | .3502 | 1.00 (0.99-1.01) | .2487 |
| PB-Eos, per increase of 100/μL | 1.03 (0.97-1.09) | .3010 | 1.06 (0.97-1.17) | .2079 |
| PB-Bas, per increase of 100/μL | 1.15 (1.01-1.29) | .0286 | 1.09 (0.91-1.30) | .3398 |
| Plt, per increase of 104/μL | 1.00 (0.99-1.01) | .6903 | 1.00 (0.99-1.02) | .5058 |
| BM-Mbl, per increase of 1% | 1.03 (1.02-1.05) | < .0001 | 1.08 (1.06-1.10) | < .0001 |
| BM-Eos, per increase of 1% | 1.07 (1.02-1.11) | .0053 | 1.06 (0.99-1.11) | .0675 |
| BM-Bas, per increase of 1% | 1.19 (1.07-1.33) | .0014 | 1.35 (1.18-1.54) | < .0001 |
| Cytogenetics | < .0001 | < .0001 | ||
| Good | 1.0 | 1.0 | ||
| Intermediate | 1.57 (1.05-2.35) | 1.95 (1.16-3.26) | ||
| High | 4.62 (3.25-6.56) | 2.86 (1.76-4.63) | ||
| IPSS | < .0001 | < .0001 | ||
| Low | 1.0 | 1.0 | ||
| Intermediate-1 | 1.39 (0.76-2.52) | 4.10 (0.98-17.20) | ||
| Intermediate-2 | 3.87 (2.10-7.11) | 12.012 (2.87-50.42) | ||
| High | 4.54 (2.41-8.55) | 26.03 (6.19-109.39) | ||
RR indicates relative risk; CI, confidence interval; PB, peripheral blood; BM, bone marrow; and Mbl, blasts.