Identification of novel splice variants in CLL-associated antigens
| Clone . | Gene . | Suggested splice variant-specific protein alteration . |
|---|---|---|
| KW-1 | KIAA1641 | Deletion of an uncharacterized protein motif (DUF164) |
| KW-4 | ZNF286 | Exclusion of the transcription-repressing KRAB domain |
| KW-6 | Ikaros | Loss of 10 aa at the activation site of Ikaros |
| KW-11 | KIAA0336 | Additional exon codes for a GTP binding site |
| KW-13 | FMNL | Full-length cloning of the gene shows 3 formin motifs (FH1, FH2, FH3) as well as 2 splice variants varying in 30 bp at the 5′ end |
| KW-14 | HGRG8 | Additional exon with unknown protein function |
| Clone . | Gene . | Suggested splice variant-specific protein alteration . |
|---|---|---|
| KW-1 | KIAA1641 | Deletion of an uncharacterized protein motif (DUF164) |
| KW-4 | ZNF286 | Exclusion of the transcription-repressing KRAB domain |
| KW-6 | Ikaros | Loss of 10 aa at the activation site of Ikaros |
| KW-11 | KIAA0336 | Additional exon codes for a GTP binding site |
| KW-13 | FMNL | Full-length cloning of the gene shows 3 formin motifs (FH1, FH2, FH3) as well as 2 splice variants varying in 30 bp at the 5′ end |
| KW-14 | HGRG8 | Additional exon with unknown protein function |
Detection of novel splice variants by sequencing positive clones detected by SEREX; in silico analysis of the protein sequence suggests alterations of the protein function.