Human activating NK cell receptors
| Receptor . | Ligand specificity . |
|---|---|
| MHC class I–specific | |
| (a) Killer immunoglobulin receptors | |
| KIR2DS1 | Group 2 HLA-C Asn77Lys80 (w2, w4, w5, w6, and related alleles) |
| KIR2DS2 | Group 1 HLA-C Ser77Asn80 (w1, w3, w7, w8, and related alleles) |
| KIR2DL4 | HLA-G |
| KIR2DS4 | Unknown |
| KIR2DS5 | Unknown |
| KIR3DS1 | Unknown |
| (b) C-type lectin receptors | |
| CD94/NKG2C | HLA-E (loaded with HLA-A, -B, -C leader peptides) |
| CD94/NKG2E/H* | Unknown |
| Non-MHC class I–specific | |
| (a) Natural cytotoxicity receptors | |
| NKp46 | Unknown |
| NKp44 | Unknown |
| NKp30 | Unknown |
| (b) C-type lectin receptor | |
| NKG2D | MICA, MICB, ULBP-1, -2, -3 |
| Other (coreceptors) | |
| CD16 (FcγRIII) | Fc of IgG |
| CD2 | CD58 (LFA-3) |
| LFA-1 | ICAM-1 |
| 2B4 | CD48 |
| NKp80 | Unknown |
| CD69 | Unknown |
| CD40 ligand | CD40 |
| Receptor . | Ligand specificity . |
|---|---|
| MHC class I–specific | |
| (a) Killer immunoglobulin receptors | |
| KIR2DS1 | Group 2 HLA-C Asn77Lys80 (w2, w4, w5, w6, and related alleles) |
| KIR2DS2 | Group 1 HLA-C Ser77Asn80 (w1, w3, w7, w8, and related alleles) |
| KIR2DL4 | HLA-G |
| KIR2DS4 | Unknown |
| KIR2DS5 | Unknown |
| KIR3DS1 | Unknown |
| (b) C-type lectin receptors | |
| CD94/NKG2C | HLA-E (loaded with HLA-A, -B, -C leader peptides) |
| CD94/NKG2E/H* | Unknown |
| Non-MHC class I–specific | |
| (a) Natural cytotoxicity receptors | |
| NKp46 | Unknown |
| NKp44 | Unknown |
| NKp30 | Unknown |
| (b) C-type lectin receptor | |
| NKG2D | MICA, MICB, ULBP-1, -2, -3 |
| Other (coreceptors) | |
| CD16 (FcγRIII) | Fc of IgG |
| CD2 | CD58 (LFA-3) |
| LFA-1 | ICAM-1 |
| 2B4 | CD48 |
| NKp80 | Unknown |
| CD69 | Unknown |
| CD40 ligand | CD40 |
Asn indicates asparagine; Lys, lysine; Ser, serine; LAIR, leukocyte-associated immunoglobulinlike receptor; Ep-CAM, epithelial cellular adhesion molecule.
NKG2E and NKG2H are splice variants.