Table 2.

Effect of diet and CBS genotype on plasma tHcy in mice

Type of dietCBS+/+ miceCBS+/− mice
Control 2.9 ± 0.3 (n = 4) 6.2 ± 1.0 (n = 6)* 
High methionine 12.6 ± 3.0 (n = 12) 30.2 ± 6.4 (n = 10)*, 
High methionine/low folate 36.4 ± 5.6 (n = 10) 92.8 ± 15.9 (n = 6)*, 
Type of dietCBS+/+ miceCBS+/− mice
Control 2.9 ± 0.3 (n = 4) 6.2 ± 1.0 (n = 6)* 
High methionine 12.6 ± 3.0 (n = 12) 30.2 ± 6.4 (n = 10)*, 
High methionine/low folate 36.4 ± 5.6 (n = 10) 92.8 ± 15.9 (n = 6)*, 

Values are mean ± SE micromoles plasma tHcy (no. of mice in group).

*

P < .05 compared with CBS+/+mice.

P < .05 compared with control diet.