Table 2.

Hematopoietic progenitors in the BM and spleen ofFanca+/+ andFanca−/− mice

SourceCellsProgenitorFanca+/+Fanca−/−
BM Total cells CFU-GM 157 ± 28 145 ± 28 
 Total cells CFU-Meg 59 ± 3 45 ± 2* 
 LinSca-1+ CFU-GM 4510 ± 1325 3650 ± 850 
Spleen Total cells CFU-GM 138 ± 18 98 ± 16 
 Total cells CFU-Meg 102 ± 6 88 ± 4 
SourceCellsProgenitorFanca+/+Fanca−/−
BM Total cells CFU-GM 157 ± 28 145 ± 28 
 Total cells CFU-Meg 59 ± 3 45 ± 2* 
 LinSca-1+ CFU-GM 4510 ± 1325 3650 ± 850 
Spleen Total cells CFU-GM 138 ± 18 98 ± 16 
 Total cells CFU-Meg 102 ± 6 88 ± 4 

Data represent the mean ± SEM values corresponding to 4 experiments involving the culture of unpurified cells and to 3 experiments involving LinSca-1+ cells. In all instances data represent the number of CFUs/5 × 104 cells.

*

Statistical significance betweenFanca+/+ and Fanca−/−groups at P < .05.