FLT3 status and relative percentage of mutant in PB or bone marrow from 44 AML patients at presentation and relapse
No. . | Presentation . | Relapse . | ||||||
---|---|---|---|---|---|---|---|---|
FLT3 . | % Mutant . | Sample . | % Blasts . | FLT3 . | % Mutant . | Sample . | % Blasts . | |
1 | WT | — | PB MNC | 90 | WT | — | NA | 76 |
2 | WT | — | BM | 97 | WT | — | PB MNC | NA |
3 | WT | — | PB MNC | 95 | WT | — | BM | NA |
4 | WT | — | PB MNC | 28 | WT | — | BM | 42 |
5 | WT | — | NA | 100 | WT | — | BM | 95 |
6 | WT | — | NA | 100 | WT | — | BM | 60 |
7 | WT | — | PB | NA | WT | — | BM | 85 |
8 | WT | — | BM | 98 | WT | — | PB | 52 |
9 | WT | — | PB | 95 | WT | — | PB | 80 |
10 | WT | — | BM | 89 | WT | — | BM | 96 |
11 | WT | — | PB | 99 | WT | — | PB | 99 |
12 | WT | — | PB | 80 | WT | — | BM | NA |
13 | WT | — | BM | 86 | WT | — | BM | 60 |
14 | WT | — | BM | 58 | WT | — | BM | 90 |
15 | WT | — | BM | 90 | WT | — | BM | 87 |
16* | WT | — | BM | 72 | WT (ITD+) | (45) | BM (PB) | 13 (87) |
17 | WT | — | BM | NA | WT | — | BM | 11 |
18 | WT | — | PB | 78 | WT | — | BM | 56 |
19 | WT | — | BM | 90 | WT | — | BM | 64 |
20 | WT | — | BM | 90 | WT | — | BM | 74 |
21 | WT | — | PB MNC | 90 | D835+ | ≈50 | PB MNC | NA |
22 | WT | — | BM | 87 | D835+ | ≈50 | BM | NA |
23 | WT | — | PB MNC | 90 | ITD+ | 42 | BM | 95 |
24 | WT | — | BM | 95 | ITD+ | 38 | BM | 95 |
25 | ITD+ | 20 | PB MNC | 53 | WT | — | BM | 55 |
26 | ITD+ | 6 | BM | 88 | WT | — | BM | 92 |
27 | ITD+ | 11 | PB | 80 | WT | — | BM | 82 |
28 | ITD+ | 28 | BM | 94 | WT | — | BM | 85 |
29 | ITD+ | 44 | BM | 95 | WT | — | BM | 44 |
30 | D835+ | ≈50 | BM | 95 | D835+ | ≈50 | BM | 96 |
31 | D835+ | ≈50 | BM | 60 | D835+ | ≈50 | BM | 60 |
32 | ITD+ | 13 | BM | 55 | ITD+ | 16 | BM | 96 |
33 | ITD+ | 39 | BM | 51 | ITD+ | 39 | BM | 60 |
34 | ITD+ | 44 | PB MNC | 77 | ITD+ | 45 | NA | NA |
35 | ITD+ | 82 | BM | 97 | ITD+ | 84 | BM | 92 |
36 | ITD+ | 86 | BM | 86 | ITD+ | 83 | PB | 93 |
37 | ITD+ | 91 | PB | 70 | ITD+ | 91 | BM | NA |
38 | ITD+ | 5 | BM | NA | ITD+ | 35 | PB | 97 |
39 | ITD+ | 23 | PB MNC | 86 | ITD+ | 88 | BM | 100 |
40 | ITD+ | 25 | PB | 79 | ITD+ | 50 | PB | 99 |
41 | ITD+ | 26 + 2 | BM | 90 | ITD+ | 56 + 14 | BM | 94 |
42 | ITD+ | 28 + 3 + 1 | BM | 80 | ITD+ | 41 | BM | 99 |
43 | ITD+ | 40 | PB MNC | 88 | ITD+ | 69 | PB MNC | NA |
44† | ITD+ | 44 | BM | 89 | ITD+ | 60 | PB | NA |
No. . | Presentation . | Relapse . | ||||||
---|---|---|---|---|---|---|---|---|
FLT3 . | % Mutant . | Sample . | % Blasts . | FLT3 . | % Mutant . | Sample . | % Blasts . | |
1 | WT | — | PB MNC | 90 | WT | — | NA | 76 |
2 | WT | — | BM | 97 | WT | — | PB MNC | NA |
3 | WT | — | PB MNC | 95 | WT | — | BM | NA |
4 | WT | — | PB MNC | 28 | WT | — | BM | 42 |
5 | WT | — | NA | 100 | WT | — | BM | 95 |
6 | WT | — | NA | 100 | WT | — | BM | 60 |
7 | WT | — | PB | NA | WT | — | BM | 85 |
8 | WT | — | BM | 98 | WT | — | PB | 52 |
9 | WT | — | PB | 95 | WT | — | PB | 80 |
10 | WT | — | BM | 89 | WT | — | BM | 96 |
11 | WT | — | PB | 99 | WT | — | PB | 99 |
12 | WT | — | PB | 80 | WT | — | BM | NA |
13 | WT | — | BM | 86 | WT | — | BM | 60 |
14 | WT | — | BM | 58 | WT | — | BM | 90 |
15 | WT | — | BM | 90 | WT | — | BM | 87 |
16* | WT | — | BM | 72 | WT (ITD+) | (45) | BM (PB) | 13 (87) |
17 | WT | — | BM | NA | WT | — | BM | 11 |
18 | WT | — | PB | 78 | WT | — | BM | 56 |
19 | WT | — | BM | 90 | WT | — | BM | 64 |
20 | WT | — | BM | 90 | WT | — | BM | 74 |
21 | WT | — | PB MNC | 90 | D835+ | ≈50 | PB MNC | NA |
22 | WT | — | BM | 87 | D835+ | ≈50 | BM | NA |
23 | WT | — | PB MNC | 90 | ITD+ | 42 | BM | 95 |
24 | WT | — | BM | 95 | ITD+ | 38 | BM | 95 |
25 | ITD+ | 20 | PB MNC | 53 | WT | — | BM | 55 |
26 | ITD+ | 6 | BM | 88 | WT | — | BM | 92 |
27 | ITD+ | 11 | PB | 80 | WT | — | BM | 82 |
28 | ITD+ | 28 | BM | 94 | WT | — | BM | 85 |
29 | ITD+ | 44 | BM | 95 | WT | — | BM | 44 |
30 | D835+ | ≈50 | BM | 95 | D835+ | ≈50 | BM | 96 |
31 | D835+ | ≈50 | BM | 60 | D835+ | ≈50 | BM | 60 |
32 | ITD+ | 13 | BM | 55 | ITD+ | 16 | BM | 96 |
33 | ITD+ | 39 | BM | 51 | ITD+ | 39 | BM | 60 |
34 | ITD+ | 44 | PB MNC | 77 | ITD+ | 45 | NA | NA |
35 | ITD+ | 82 | BM | 97 | ITD+ | 84 | BM | 92 |
36 | ITD+ | 86 | BM | 86 | ITD+ | 83 | PB | 93 |
37 | ITD+ | 91 | PB | 70 | ITD+ | 91 | BM | NA |
38 | ITD+ | 5 | BM | NA | ITD+ | 35 | PB | 97 |
39 | ITD+ | 23 | PB MNC | 86 | ITD+ | 88 | BM | 100 |
40 | ITD+ | 25 | PB | 79 | ITD+ | 50 | PB | 99 |
41 | ITD+ | 26 + 2 | BM | 90 | ITD+ | 56 + 14 | BM | 94 |
42 | ITD+ | 28 + 3 + 1 | BM | 80 | ITD+ | 41 | BM | 99 |
43 | ITD+ | 40 | PB MNC | 88 | ITD+ | 69 | PB MNC | NA |
44† | ITD+ | 44 | BM | 89 | ITD+ | 60 | PB | NA |