Table 2. γ Globin chain synthesis Animal... | American Society of Hematology

Table 2.

γ Globin chain synthesis

Animal	Compound	γ Globin synthesis,	γ Globin synthesis,
		% Baseline	% Treatment
3698	DMB	3.1	6.4
1997	DMB	7.0	19.6
2063	DMB	0	4.0
196	AMHCA	0	14.6
1573	AMHCA	3.7	13.7
2063	AMHCA	0	2.0

Animal	Compound	γ Globin synthesis,	γ Globin synthesis,
		% Baseline	% Treatment
3698	DMB	3.1	6.4
1997	DMB	7.0	19.6
2063	DMB	0	4.0
196	AMHCA	0	14.6
1573	AMHCA	3.7	13.7
2063	AMHCA	0	2.0

γ Globin chain synthesis in baboons before and during treatment with AMHCA or DMB. Treatment with the compounds produced an increase in γ globin chain synthesis over baseline; the ratio of γ/γ+β globin × 100 is shown. Doses administered were 200 mg/kg/day for 4 to 6 days, except for animal 2063, which received 150 mg/kg per dose.

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