Table 2. Tumor clonality and EBV gene... | American Society of Hematology

Table 2.

Tumor clonality and EBV gene expression in 11 renal transplantation patients with PTLD

Patient no.	EBER (ISH)	LMP-1 (IHC)	Clone	κ/λ	Immunoglobulin heavy chain	EBV vTK (IS-RT-PCR)
1	+	−		NA	NA	NA
2	ND	+		κ	HC2	2+
3	+	−	1	κ	HC1	3+
			2	λ	HC3	1+
4	ND	+		NA	NA	NA
5	+	−		NA	NA	NA
6	ND	+	1	κ	HC6	3+
			2	λ	HC6	3+
			3	κ	HC1	1+
7	+	−		λ	HC2	3+
8	ND	+	1	Both	HC4/HC2	1+/2+
			2	Both	HC2;6/HC4	1+/1+
9	+	−		Both	HC3/HC5	3+
10	−	−	1	λ	NA	2+
			2	λ	HC5	1+
			3	κ	HC5	1+
11	−	−	1	λ	HC3	3+
			2	κ	HC3	2+
			3	λ	HC4/HC2	2+

Patient no.	EBER (ISH)	LMP-1 (IHC)	Clone	κ/λ	Immunoglobulin heavy chain	EBV vTK (IS-RT-PCR)
1	+	−		NA	NA	NA
2	ND	+		κ	HC2	2+
3	+	−	1	κ	HC1	3+
			2	λ	HC3	1+
4	ND	+		NA	NA	NA
5	+	−		NA	NA	NA
6	ND	+	1	κ	HC6	3+
			2	λ	HC6	3+
			3	κ	HC1	1+
7	+	−		λ	HC2	3+
8	ND	+	1	Both	HC4/HC2	1+/2+
			2	Both	HC2;6/HC4	1+/1+
9	+	−		Both	HC3/HC5	3+
10	−	−	1	λ	NA	2+
			2	λ	HC5	1+
			3	κ	HC5	1+
11	−	−	1	λ	HC3	3+
			2	κ	HC3	2+
			3	λ	HC4/HC2	2+

ISH indicates in situ hybridization; IHC, immunohistochemistry; IS-RT-PCR, in situ RT-PCR; NA, tissue not available for analysis; ND, not done.