Nomogram for managing heparin infusion according to monitoring of APTT or anti–factor Xa levels
| APTT (s) . | Anti–factor Xa level (IU/mL)* . | Bolus (U/kg) . | Hold (min) . | Rate change (%) . |
|---|---|---|---|---|
| <50 | <0.1 | 50 | — | ↑ 20 |
| 50-59 | 0.1-0.34 | — | — | ↑ 10 |
| 60-85 | 0.35-0.70 | — | — | No change |
| 86-95 | 0.71-0.89 | — | — | ↓ 10 |
| 96-120 | 0.9-1.2 | — | 30 | ↓ 10 |
| >120 | >1.2 | — | 60 | ↓ 15 |
| APTT (s) . | Anti–factor Xa level (IU/mL)* . | Bolus (U/kg) . | Hold (min) . | Rate change (%) . |
|---|---|---|---|---|
| <50 | <0.1 | 50 | — | ↑ 20 |
| 50-59 | 0.1-0.34 | — | — | ↑ 10 |
| 60-85 | 0.35-0.70 | — | — | No change |
| 86-95 | 0.71-0.89 | — | — | ↓ 10 |
| 96-120 | 0.9-1.2 | — | 30 | ↓ 10 |
| >120 | >1.2 | — | 60 | ↓ 15 |
This assumes that the APTT range of 60 to 85 seconds correlates with an anti–factor Xa level of 0.35 to 0.70 IU/mL. This will depend on the reagent and analyzer used in the laboratory.21
—, not applicable.