Patients with toxicity
| . | Grade 1-2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| Toxicity (%) | ||||
| Hematologic/infectious | ||||
| Neutropenia | 16 (21) | 8 (10) | 45 (58) | — |
| Leukopenia | 20 (26) | 21 (27) | 35 (45) | — |
| Infection | 28 (36) | 12 (15) | 7 (9) | 2 (3) |
| Anemia | 32 (41) | 38 (49) | 6 (8) | — |
| Thrombocytopenia | 32 (41) | 18 (23) | 16 (21) | — |
| Hemorrhage | 10 (3) | 2 (3) | 1 (1) | — |
| Gastrointestinal | ||||
| Nausea | 49 (63) | 8 (10) | 0 | — |
| Vomiting | 28 (36) | 3 (4) | 1 (1) | — |
| Stomatitis | 42 (54) | 3 (4) | 1 (1) | — |
| Diarrhea | 28 (36) | 0 | 1 (1) | — |
| Liver | 52 (67) | 2 (3) | 1 (1) | — |
| Cardiopulmonary | ||||
| Cardiac | 17 (22) | 2 (3) | 0 | — |
| Pulmonary | 23 (29) | 0 | 3 (4) | — |
| Other toxicities (%) | ||||
| Weight loss | 40 (51) | 0 | 0 | — |
| Weight gain | 11 (14) | 2 (3) | 0 | — |
| Fever (no infection) | 47 (60) | 1 (1) | 1 (1) | — |
| Metabolic | 22 (28) | 5 (6) | 2 (3) | — |
| Genitourinary | 10 (13) | 1 (1) | 0 | — |
| Neuromotor | 29 (37) | 4 (5) | 0 | — |
| Neurosensory | 10 (13) | 3 (4) | 1 (1) | — |
| Neuropsychologic | 12 (15) | 1 (1) | 0 | — |
| Neuroclinical | 6 (8) | 4 (5) | 0 | — |
| Fatigue | 22 (28) | 4 (5) | 0 | — |
| Skin | 16 (21) | 1 (1) | 0 | — |
| Phlebitis | 7 (9) | 2 (3) | 1 (1) | — |
| Worst-degree, nonhematologic (%) | 19 (24) | 38 (49) | 18 (23) | 2 (3) |
| . | Grade 1-2 . | Grade 3 . | Grade 4 . | Grade 5 . |
|---|---|---|---|---|
| Toxicity (%) | ||||
| Hematologic/infectious | ||||
| Neutropenia | 16 (21) | 8 (10) | 45 (58) | — |
| Leukopenia | 20 (26) | 21 (27) | 35 (45) | — |
| Infection | 28 (36) | 12 (15) | 7 (9) | 2 (3) |
| Anemia | 32 (41) | 38 (49) | 6 (8) | — |
| Thrombocytopenia | 32 (41) | 18 (23) | 16 (21) | — |
| Hemorrhage | 10 (3) | 2 (3) | 1 (1) | — |
| Gastrointestinal | ||||
| Nausea | 49 (63) | 8 (10) | 0 | — |
| Vomiting | 28 (36) | 3 (4) | 1 (1) | — |
| Stomatitis | 42 (54) | 3 (4) | 1 (1) | — |
| Diarrhea | 28 (36) | 0 | 1 (1) | — |
| Liver | 52 (67) | 2 (3) | 1 (1) | — |
| Cardiopulmonary | ||||
| Cardiac | 17 (22) | 2 (3) | 0 | — |
| Pulmonary | 23 (29) | 0 | 3 (4) | — |
| Other toxicities (%) | ||||
| Weight loss | 40 (51) | 0 | 0 | — |
| Weight gain | 11 (14) | 2 (3) | 0 | — |
| Fever (no infection) | 47 (60) | 1 (1) | 1 (1) | — |
| Metabolic | 22 (28) | 5 (6) | 2 (3) | — |
| Genitourinary | 10 (13) | 1 (1) | 0 | — |
| Neuromotor | 29 (37) | 4 (5) | 0 | — |
| Neurosensory | 10 (13) | 3 (4) | 1 (1) | — |
| Neuropsychologic | 12 (15) | 1 (1) | 0 | — |
| Neuroclinical | 6 (8) | 4 (5) | 0 | — |
| Fatigue | 22 (28) | 4 (5) | 0 | — |
| Skin | 16 (21) | 1 (1) | 0 | — |
| Phlebitis | 7 (9) | 2 (3) | 1 (1) | — |
| Worst-degree, nonhematologic (%) | 19 (24) | 38 (49) | 18 (23) | 2 (3) |
n = 78.
Based on NCI Common Toxicity Criteria.