In vivo activity of ST1346 and ATRA in the SCID mouse receiving transplanted NB4 cells
| Treatment . | Dose, mg/kg . | Lethality . | BWL, % . | MST (range) . | MST . | ILS, % . |
|---|---|---|---|---|---|---|
| Vehicle | — | 0/7 | 0 | (39-46) | 43 | — |
| ATRA | 5 | 0/7 | 0 | (42-63) | 45 | 5 |
| ST1346 | 15 | 0/7 | 0 | (34-48) | 39 | — |
| ST1346 | 30 | 0/6 | 0 | (36-64) | 40 | — |
| ATRA + ST1346 | 5 + 15 | 0/7 | 0 | (42-65) | 49 | 14 |
| ATRA + ST1346 | 5 + 30 | 0/7 | 0 | (46-70) | 603-150,3-151 | 40 |
| Treatment . | Dose, mg/kg . | Lethality . | BWL, % . | MST (range) . | MST . | ILS, % . |
|---|---|---|---|---|---|---|
| Vehicle | — | 0/7 | 0 | (39-46) | 43 | — |
| ATRA | 5 | 0/7 | 0 | (42-63) | 45 | 5 |
| ST1346 | 15 | 0/7 | 0 | (34-48) | 39 | — |
| ST1346 | 30 | 0/6 | 0 | (36-64) | 40 | — |
| ATRA + ST1346 | 5 + 15 | 0/7 | 0 | (42-65) | 49 | 14 |
| ATRA + ST1346 | 5 + 30 | 0/7 | 0 | (46-70) | 603-150,3-151 | 40 |
SCID mice were xenografted with NB4 cells intraperitoneally and treated as stated in “Materials and methods” with the indicated dosages of ATRA and/or ST1346 5 times per week for 3 weeks. BWL% max indicates maximum body weight loss during the treatment; MST, mean survival time; ILS%, increase in lifespan (MST treated/MST control ×100) – 100.
Significantly higher than the vehicle–treated experimental group (P < .01, according to the Mann–Whitney test following analysis of variance [ANOVA]).
Significantly higher than the ATRA–treated experimental group (P < .05, according to the Mann–Whitney test following ANOVA).