Tissue repair approaches (alphabetical order)
| Name . | Source and function . | Role in GVHD . | Species analyzed . | Reference . |
|---|---|---|---|---|
| IL-22 | Produced by ILC3, splenic LTi-like cells, Th17 cells | IL-22 is protective in mouse models of acute GVHD | Mouse | 43,44 |
| Promotes ISC expansion | Clinical trial on IL-22 IgG2-Fc (F-652), NCT02406651 | Human | ||
| Can trigger inflammation in the presence of IL-17S | ||||
| KGF | Produced by intraepithelial TCR γ/δ cells and mesenchymal cells | Reduced acute GVHD in mouse models | Mouse | 46 |
| Leads to expansion of intestinal epithelial cells | A phase 1/2 randomized placebo-controlled trial showed that KGF did not reduce acute GVHD but did lower mucositis rates in patients conditioned with more intensive TBI | Human | 47 | |
| R-spo-1 | Produced by the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea | R-Spo1 reduced acute GVHD in the mouse model by protecting ISC from conditioning injury | Mouse | 49,50 |
| R-spo1 induces increased internalization of LGR5 on ISC and Paneth cells, which leads to their expansion | R-Spo1 protects Paneth cells and leads to a more diverse intestinal microbiome |
| Name . | Source and function . | Role in GVHD . | Species analyzed . | Reference . |
|---|---|---|---|---|
| IL-22 | Produced by ILC3, splenic LTi-like cells, Th17 cells | IL-22 is protective in mouse models of acute GVHD | Mouse | 43,44 |
| Promotes ISC expansion | Clinical trial on IL-22 IgG2-Fc (F-652), NCT02406651 | Human | ||
| Can trigger inflammation in the presence of IL-17S | ||||
| KGF | Produced by intraepithelial TCR γ/δ cells and mesenchymal cells | Reduced acute GVHD in mouse models | Mouse | 46 |
| Leads to expansion of intestinal epithelial cells | A phase 1/2 randomized placebo-controlled trial showed that KGF did not reduce acute GVHD but did lower mucositis rates in patients conditioned with more intensive TBI | Human | 47 | |
| R-spo-1 | Produced by the developing central nervous system, as well as in the adrenal glands, ovary, testis, thyroid, and trachea | R-Spo1 reduced acute GVHD in the mouse model by protecting ISC from conditioning injury | Mouse | 49,50 |
| R-spo1 induces increased internalization of LGR5 on ISC and Paneth cells, which leads to their expansion | R-Spo1 protects Paneth cells and leads to a more diverse intestinal microbiome |
TCR, T-cell receptor.