Demographic data and major immunologic findings in A-T patients
| Patient . | Age, y/sex . | Lymphs/μL . | CD19 . | CD4 . | CD8 . | T-cell phenotype . | Cytokine production . | TRECs . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Naive . | Memory . | “Effector” memory . | CD4 . | CD8 . | |||||||||||||||
| CD4 . | CD8 . | CD4 . | CD8 . | CD4 . | CD8 . | IL-2 . | IFN-γ . | IL-4 . | IL-2 . | IFN-γ . | IL-4 . | CD4 . | CD8 . | ||||||
| 1 | 7/M | 961 | 34 | 22 | 24 | 2 | 16 | 98 | 84 | 22 | 39 | 55 | 41 | 9 | 18 | 76 | 9 | 4.3 | 5.3 |
| 2 | 10/F | 710 | ND | 38 | 17 | 6 | 15 | 93 | 86 | 27 | 54 | ND | ND | ND | ND | ND | ND | 4 | 7.9 |
| 3 | 11/F | 1260 | 1 | 23 | 30 | 3 | 20 | 95 | 79 | 26 | 53 | 56 | 55 | 3 | 18 | 81 | 1 | 0 | 18.5 |
| 4 | 12/M | 660 | ND | 37 | 21 | 10 | 24 | 89 | 76 | 27 | 43 | ND | ND | ND | ND | ND | ND | 6 | <2 |
| 5 | 13/F | 976 | 5 | 21 | 10 | 2 | 10 | 97 | 91 | 27 | 51 | 51 | 51 | 13 | 9 | 85 | 3 | <2 | <2 |
| 6 | 17/F | 860 | 3 | 29 | 14 | 5 | 25 | 94 | 75 | 15 | 29 | 67 | 35 | 15 | 50 | 63 | 19 | ND | ND |
| 7 | 21/F | 1140 | 7 | 48 | 9 | 54 | 23 | 46 | 77 | 13 | 63 | 57 | 10 | 0.7 | 14 | 61 | 2 | 5.9 | <2 |
| 8 | 21/M | 872 | 5 | 38 | 27 | 25 | 26 | 75 | 74 | 18 | 37 | 56 | 13 | 6 | 37 | 39 | 14 | 4 | 2.8 |
| 9 | 32/M | 1320 | 6 | 23 | 27 | 16 | 40 | 83 | 60 | 17 | 40 | 50 | 30 | 1.2 | 11 | 24 | 0.1 | ND | ND |
| Normal* | |||||||||||||||||||
| 6-12 | >1200 | 9-20 (12) | 32-51 (41) | 10-24 (21) | 53-87 (65) | 60-91 (74) | 13-47 (30) | 9-39 (23) | 1-10 (7) | 7-28 (19) | 41-55 (49) | 3-12 (7) | 1-3 (2) | 11-19 (16) | 9-48 (17) | 0-1 (1) | |||
| 13-35 | >1200 | 5-21 (11) | 39-54 (45) | 13-31 (19) | 37-69 (49) | 49-79 (69) | 31-63 (51) | 21-51 (30) | 5-16 (10) | 12-38 (20) | 61-75 (63) | 12-19 (14) | 3-6 (5) | 27-36 (28) | 32-40 (34) | 1-2.3 (1.5) | 120-340 (170) | 90-240 (145) | |
| Patient . | Age, y/sex . | Lymphs/μL . | CD19 . | CD4 . | CD8 . | T-cell phenotype . | Cytokine production . | TRECs . | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Naive . | Memory . | “Effector” memory . | CD4 . | CD8 . | |||||||||||||||
| CD4 . | CD8 . | CD4 . | CD8 . | CD4 . | CD8 . | IL-2 . | IFN-γ . | IL-4 . | IL-2 . | IFN-γ . | IL-4 . | CD4 . | CD8 . | ||||||
| 1 | 7/M | 961 | 34 | 22 | 24 | 2 | 16 | 98 | 84 | 22 | 39 | 55 | 41 | 9 | 18 | 76 | 9 | 4.3 | 5.3 |
| 2 | 10/F | 710 | ND | 38 | 17 | 6 | 15 | 93 | 86 | 27 | 54 | ND | ND | ND | ND | ND | ND | 4 | 7.9 |
| 3 | 11/F | 1260 | 1 | 23 | 30 | 3 | 20 | 95 | 79 | 26 | 53 | 56 | 55 | 3 | 18 | 81 | 1 | 0 | 18.5 |
| 4 | 12/M | 660 | ND | 37 | 21 | 10 | 24 | 89 | 76 | 27 | 43 | ND | ND | ND | ND | ND | ND | 6 | <2 |
| 5 | 13/F | 976 | 5 | 21 | 10 | 2 | 10 | 97 | 91 | 27 | 51 | 51 | 51 | 13 | 9 | 85 | 3 | <2 | <2 |
| 6 | 17/F | 860 | 3 | 29 | 14 | 5 | 25 | 94 | 75 | 15 | 29 | 67 | 35 | 15 | 50 | 63 | 19 | ND | ND |
| 7 | 21/F | 1140 | 7 | 48 | 9 | 54 | 23 | 46 | 77 | 13 | 63 | 57 | 10 | 0.7 | 14 | 61 | 2 | 5.9 | <2 |
| 8 | 21/M | 872 | 5 | 38 | 27 | 25 | 26 | 75 | 74 | 18 | 37 | 56 | 13 | 6 | 37 | 39 | 14 | 4 | 2.8 |
| 9 | 32/M | 1320 | 6 | 23 | 27 | 16 | 40 | 83 | 60 | 17 | 40 | 50 | 30 | 1.2 | 11 | 24 | 0.1 | ND | ND |
| Normal* | |||||||||||||||||||
| 6-12 | >1200 | 9-20 (12) | 32-51 (41) | 10-24 (21) | 53-87 (65) | 60-91 (74) | 13-47 (30) | 9-39 (23) | 1-10 (7) | 7-28 (19) | 41-55 (49) | 3-12 (7) | 1-3 (2) | 11-19 (16) | 9-48 (17) | 0-1 (1) | |||
| 13-35 | >1200 | 5-21 (11) | 39-54 (45) | 13-31 (19) | 37-69 (49) | 49-79 (69) | 31-63 (51) | 21-51 (30) | 5-16 (10) | 12-38 (20) | 61-75 (63) | 12-19 (14) | 3-6 (5) | 27-36 (28) | 32-40 (34) | 1-2.3 (1.5) | 120-340 (170) | 90-240 (145) | |
All data are expressed as percentages except for absolute lymphocyte counts and TRECs (number of copies/100 ng DNA).
M indicates male; F, female; and ND, not determined.
Range (median) for the indicated age groups. The age range of the control group for TRECs is 10 to 20 years.