Randomized studies comparing single vs tandem ASCT
| Study . | First ASCT . | Consolidation s/p first ASCT . | Maintenance . | EFS . | OS . | Salvage ASCT at relapse . |
|---|---|---|---|---|---|---|
| IFM9454 | MEL140 + TBI (single arm) | None vs MEL140 + TBI | Interferon α | Median EFS: 25 (single) vs 30 (tandem) mo (P = .03) | Median OS: 48 (single) vs 58 (tandem) mo (P = .01) | 22% (single arm) vs 26% (tandem arm) |
| MEL140 (tandem arm) | ||||||
| Bologna 7655 | MEL200 | None vs MEL120 + busulfan | Interferon α | Median EFS: 23 (single) vs 25 (tandem) mo (P = .001) | 7-y OS: 46% (single) vs 43% (tandem) (P = .9) | 33% (single arm) vs 10% (tandem arm) |
| GMMG-HD213 | MEL200 | None vs second ASCT with MEL200 | Interferon α | Median EFS: 25 (single) vs 28.7 (tandem) mo (P = .53) | Median OS: 73 (single) vs 75.3 (tandem) mo (P = .33) | 26% (single arm) vs 24% (tandem arm) |
| BMT CTN 0702 (NCT01109004) | MEL200 | None vs RVD ×4 vs second ASCT with MEL200 | Len until progression for all arms | Not yet reported | Not yet reported | Not yet reported |
| Study . | First ASCT . | Consolidation s/p first ASCT . | Maintenance . | EFS . | OS . | Salvage ASCT at relapse . |
|---|---|---|---|---|---|---|
| IFM9454 | MEL140 + TBI (single arm) | None vs MEL140 + TBI | Interferon α | Median EFS: 25 (single) vs 30 (tandem) mo (P = .03) | Median OS: 48 (single) vs 58 (tandem) mo (P = .01) | 22% (single arm) vs 26% (tandem arm) |
| MEL140 (tandem arm) | ||||||
| Bologna 7655 | MEL200 | None vs MEL120 + busulfan | Interferon α | Median EFS: 23 (single) vs 25 (tandem) mo (P = .001) | 7-y OS: 46% (single) vs 43% (tandem) (P = .9) | 33% (single arm) vs 10% (tandem arm) |
| GMMG-HD213 | MEL200 | None vs second ASCT with MEL200 | Interferon α | Median EFS: 25 (single) vs 28.7 (tandem) mo (P = .53) | Median OS: 73 (single) vs 75.3 (tandem) mo (P = .33) | 26% (single arm) vs 24% (tandem arm) |
| BMT CTN 0702 (NCT01109004) | MEL200 | None vs RVD ×4 vs second ASCT with MEL200 | Len until progression for all arms | Not yet reported | Not yet reported | Not yet reported |
s/p, status-post; TBI, total body irradiation.