Examples of recurrent AML mutations by functional group
| Functional class . | Specific example mutations . |
|---|---|
| Signaling and kinase pathway | FLT3, KRAS, NRAS, KIT, PTPN11, and NF1 |
| Epigenetic modifiers (DNA methylation and chromatin modification) | DNMT3A, IDH1, IDH2, TET2, ASXL1, EZH2, and MLL/KMT2A |
| Nucleophosmin | NPM1 |
| Transcription factors | CEBPA, RUNX1, and GATA2 |
| Tumor suppressors | TP53 |
| Spliceosome complex | SRSF2, U2AF1, SF3B1, and ZRSR2 |
| Cohesin complex* | RAD21, STAG1, STAG2, SMC1A, and SMC3 |
| Functional class . | Specific example mutations . |
|---|---|
| Signaling and kinase pathway | FLT3, KRAS, NRAS, KIT, PTPN11, and NF1 |
| Epigenetic modifiers (DNA methylation and chromatin modification) | DNMT3A, IDH1, IDH2, TET2, ASXL1, EZH2, and MLL/KMT2A |
| Nucleophosmin | NPM1 |
| Transcription factors | CEBPA, RUNX1, and GATA2 |
| Tumor suppressors | TP53 |
| Spliceosome complex | SRSF2, U2AF1, SF3B1, and ZRSR2 |
| Cohesin complex* | RAD21, STAG1, STAG2, SMC1A, and SMC3 |
Not discussed in detail within the manuscript.