Table 3.

Summary of non-neurological indications for long term transfusion11,12,15 

IndicationComment
Recurrent pain crisis Consider if hydroxyurea ineffective or contraindicated 
Recurrent acute chest syndrome Consider if hydroxyurea ineffective or contraindicated 
Recurrent priapism Consider if lack of response to other treatments 
Leg ulcers Consider if lack of response to other treatments or in context of clinical trial 
Pulmonary hypertension Consider on case by case basis or in context of clinical trial 
Post renal or liver transplantation Consider on case by case basis 
IndicationComment
Recurrent pain crisis Consider if hydroxyurea ineffective or contraindicated 
Recurrent acute chest syndrome Consider if hydroxyurea ineffective or contraindicated 
Recurrent priapism Consider if lack of response to other treatments 
Leg ulcers Consider if lack of response to other treatments or in context of clinical trial 
Pulmonary hypertension Consider on case by case basis or in context of clinical trial 
Post renal or liver transplantation Consider on case by case basis 

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