Adverse events through induction
| . | Any grade . | Grade 3/4 . | |
|---|---|---|---|
| . | VRD GEM2012 (N = 458) . | VRD GEM2012 (n = 458) . | VTD GEM2005* (n = 130) . |
| Hematologic | |||
| Neutropenia | 146 (31.9)† | 59 (12.9) | 13 (10) |
| Thrombocytopenia | 116 (25.3) | 29 (6.3) | 10 (8) |
| Nonhematologic | |||
| Peripheral neuropathy | 174 (38.0)‡ | 18 (3.9)‡ | 17 (13) |
| Infection | 129 (28.2)† | 42 (9.2) | 27 (21) |
| Skin toxicity | 91 (19.9) | 14 (3.1) | |
| Pneumonia | 24 (5.2)† | 10 (2.2) | |
| . | Any grade . | Grade 3/4 . | |
|---|---|---|---|
| . | VRD GEM2012 (N = 458) . | VRD GEM2012 (n = 458) . | VTD GEM2005* (n = 130) . |
| Hematologic | |||
| Neutropenia | 146 (31.9)† | 59 (12.9) | 13 (10) |
| Thrombocytopenia | 116 (25.3) | 29 (6.3) | 10 (8) |
| Nonhematologic | |||
| Peripheral neuropathy | 174 (38.0)‡ | 18 (3.9)‡ | 17 (13) |
| Infection | 129 (28.2)† | 42 (9.2) | 27 (21) |
| Skin toxicity | 91 (19.9) | 14 (3.1) | |
| Pneumonia | 24 (5.2)† | 10 (2.2) | |
Data are n (%). Common Terminology Criteria for Adverse Events v4.03 was used for GEM2012, and v3.0 was used for GEM2012. Grade ≥3 adverse events were reported in ≥2% of patients in GEM2012.
Data from Rosiñol at al.12
Includes 1 patient who died due to neutropenia, 4 patients who died due to infection, and 2 patients who died due to pneumonia.
Grouped term; includes peripheral neuropathy, neuralgia, polyneuropathy, and sensory loss.