Table 1. Response rates and kinetics on... | American Society of Hematology

Table 1.

Response rates and kinetics on ibrutinib in WM patients according to CXCR4^S338Xmutational status and clonality

	CXCR4^S338X clonality		CXCR4^WT, n = 110	P
	High, n = 23	Low, n = 14	CXCR4^WT, n = 110	P
Overall response, n (%)	22 (96)	12 (86)	106 (96)	.19
Major response, n (%)	15 (65)	8 (57)	94 (85)	.004
Very good partial response, n (%)	1 (4)	3 (21)	38 (35)	.01
Time to minor response, mo	2.1	1.8	1.1	.0001
Time to major response, mo	9.7	7.4	1.9	.0003

	CXCR4^S338X clonality		CXCR4^WT, n = 110	P
	High, n = 23	Low, n = 14	CXCR4^WT, n = 110	P
Overall response, n (%)	22 (96)	12 (86)	106 (96)	.19
Major response, n (%)	15 (65)	8 (57)	94 (85)	.004
Very good partial response, n (%)	1 (4)	3 (21)	38 (35)	.01
Time to minor response, mo	2.1	1.8	1.1	.0001
Time to major response, mo	9.7	7.4	1.9	.0003