Hematologic, kidney, and liver function indicators for untreated control and 211At-CD38 45-µCi–treated mice bearing disseminated OPM-2Luc xenografts, and age-matched mice with no disease
| Treatment group . | Day . | WBC, ×109/L . | Hematocrit, % . | Platelets, ×109/L . | Creatinine, mg/dL . | ALT, U/L . |
|---|---|---|---|---|---|---|
| Untreated control | 14 | 1.8 ± 0.3 (5) | 52 ± 1.4 (5) | 1602 ± 399 (5) | 0.52 ± 0.04 (5) | 26 ± 4 (5) |
| 211At-CD38 45 µCi | 2.4 ± 0.5 (4) | 46 ± 2.6 (5) | 865 ± 86 (4) | 0.52 ± 0.04 (5) | 27 ± 4 (5) | |
| Age-matched control | 2.2 ± 0.3 (2) | 53 ± 4.1 (3) | 1719 ± 90 (3) | 0.57 ± 0.12 (3) | 20 ± 4 (3) | |
| Untreated control | 32 | 2.1 ± 0.8 (5) | 56 ± 2.6 (5) | 1444 ± 313 (5) | 0.46 ± 0.05 (5) | 77 ± 16 (5) |
| 211At-CD38 45 µCi | 1.5 ± 0.1 (4) | 54 ± 2.7 (5) | 1328 ± 120 (4) | 0.52 ± 0.04 (5) | 52 ± 21 (5) | |
| Age-matched control | 1.6 ± 0.2 (3) | 58 ± 2.9 (3) | 1929 ± 252 (3) | 0.50 ± 0.01 (3) | 44 ± 6 (3) | |
| 211At-CD38 45 µCi | 148 | 1.3 ± 0.6 (2) | 42 ± 0.6 (4) | 1394 ± 68 (2) | 0.58 ± 0.05 (4) | 51 ± 10 (4) |
| Age-matched control | 1.5 ± 1.0 (3) | 46 ± 0.6 (3) | 1773 ± 76 (3) | 0.50 ± 0.01 (3) | 24 ± 5 (3) |
| Treatment group . | Day . | WBC, ×109/L . | Hematocrit, % . | Platelets, ×109/L . | Creatinine, mg/dL . | ALT, U/L . |
|---|---|---|---|---|---|---|
| Untreated control | 14 | 1.8 ± 0.3 (5) | 52 ± 1.4 (5) | 1602 ± 399 (5) | 0.52 ± 0.04 (5) | 26 ± 4 (5) |
| 211At-CD38 45 µCi | 2.4 ± 0.5 (4) | 46 ± 2.6 (5) | 865 ± 86 (4) | 0.52 ± 0.04 (5) | 27 ± 4 (5) | |
| Age-matched control | 2.2 ± 0.3 (2) | 53 ± 4.1 (3) | 1719 ± 90 (3) | 0.57 ± 0.12 (3) | 20 ± 4 (3) | |
| Untreated control | 32 | 2.1 ± 0.8 (5) | 56 ± 2.6 (5) | 1444 ± 313 (5) | 0.46 ± 0.05 (5) | 77 ± 16 (5) |
| 211At-CD38 45 µCi | 1.5 ± 0.1 (4) | 54 ± 2.7 (5) | 1328 ± 120 (4) | 0.52 ± 0.04 (5) | 52 ± 21 (5) | |
| Age-matched control | 1.6 ± 0.2 (3) | 58 ± 2.9 (3) | 1929 ± 252 (3) | 0.50 ± 0.01 (3) | 44 ± 6 (3) | |
| 211At-CD38 45 µCi | 148 | 1.3 ± 0.6 (2) | 42 ± 0.6 (4) | 1394 ± 68 (2) | 0.58 ± 0.05 (4) | 51 ± 10 (4) |
| Age-matched control | 1.5 ± 1.0 (3) | 46 ± 0.6 (3) | 1773 ± 76 (3) | 0.50 ± 0.01 (3) | 24 ± 5 (3) |
Data are mean ± 1 SD (n).
ALT, alanine aminotransferase; WBC, white blood cell.