Table 1. Clinicopathologic features of... | American Society of Hematology

Table 1.

Clinicopathologic features of NK-cell enteropathy

Case	Age, y	Sex	Symptoms	GI involvement	Endoscopic	Tumor content, %	CD56	CD2	CD3	CD7	Ki-67	pSTAT5	TCRG PCR	Follow-up, months	Status
1	65	M	Reflux	S	Diffuse erythema and a polyp in antrum and body of stomach	50	P	N	Cyto	P	75-90%	ND	Polyclonal	45	Alive, no rebiopsy, treated for H pylori
2	76	F	Diverticulosis, stool blood test +	S, D	Multiple gastric ulcers and duodenal ulcers, erosive gastritis	20	P	P	Cyto	P	25-50%	P	Polyclonal	48	Alive, rebiopsies showed persistent disease, no treatment
3	31	M	None; family history of colon cancer	C, S	Not known	20	P	N	Cyto	N	25-50%	P	Polyclonal	84	Alive with rebiopsies showed persistent disease, treatment unclear
4	63	F	Upper GI discomfort, mild duodenal wall thickening on abdominal computed tomography	D	Duodenal polyp with erosion	30	P	N	Cyto	ND	25-50%	P	ND	Lost follow-up
5	71	F	Not known	S, C	Ulceration in colon and terminal ileum	20	P	P	Cyto	P	25-50%	ND	Restricted	96	Rebiopsies showed persistent disease for 4 y, but last 1 unremarkable, treatment unclear
6	48	F	Persistent diarrhea, outside called T-cell lymphoma on small bowel resection. Received 1 cycle of chemotherapy	S, D, and TI	Not known	15	Indeterminate	ND	Cyto	ND	ND	P	Polyclonal	95	Alive, no rebiopsy, no treatment
7	69	F	Recurrent gastric and duodenal ulcers, prior history of H pylori	S, D	Not known	50	P	P	Cyto	P	50-75%	P	Polyclonal	Lost follow-up
8	9	F	Abdominal pain, daily vomit, failure to gain weight since age 6 y (for past 3 y)	S, proximal small intestine	Hyperemia and multiple ulcers in the stomach and multiple ulcers and stenosis in the duodenum	60	P	partial	Partial; cyto	ND	ND	P	ND	47	Subcutaneous methotrexate, healthy
9	38	M	History of PSC, colonoscopy done for PSC work up to rule out IBD	C, TI	Ulcers and papules from ileum to the rectum	30	P	ND	Cyto	ND	75-90%	suboptimal	Restricted	71	Liver transplant for PSC 4 y later. Rebiopsy before the transplant showed persistent disease. On immunosuppression but asymptomatic and PET was negative
10	59	F	Upper GI discomfort, PET SUV 4 of gastric fundus; outside called NK/T-cell lymphoma, consult for HSCT and chemotherapy	S	Ulcer	40	P	P	Cyto	P	25-50%	P	Polyclonal	24	Alive, no rebiopsy or treatment

Case	Age, y	Sex	Symptoms	GI involvement	Endoscopic	Tumor content, %	CD56	CD2	CD3	CD7	Ki-67	pSTAT5	TCRG PCR	Follow-up, months	Status
1	65	M	Reflux	S	Diffuse erythema and a polyp in antrum and body of stomach	50	P	N	Cyto	P	75-90%	ND	Polyclonal	45	Alive, no rebiopsy, treated for H pylori
2	76	F	Diverticulosis, stool blood test +	S, D	Multiple gastric ulcers and duodenal ulcers, erosive gastritis	20	P	P	Cyto	P	25-50%	P	Polyclonal	48	Alive, rebiopsies showed persistent disease, no treatment
3	31	M	None; family history of colon cancer	C, S	Not known	20	P	N	Cyto	N	25-50%	P	Polyclonal	84	Alive with rebiopsies showed persistent disease, treatment unclear
4	63	F	Upper GI discomfort, mild duodenal wall thickening on abdominal computed tomography	D	Duodenal polyp with erosion	30	P	N	Cyto	ND	25-50%	P	ND	Lost follow-up
5	71	F	Not known	S, C	Ulceration in colon and terminal ileum	20	P	P	Cyto	P	25-50%	ND	Restricted	96	Rebiopsies showed persistent disease for 4 y, but last 1 unremarkable, treatment unclear
6	48	F	Persistent diarrhea, outside called T-cell lymphoma on small bowel resection. Received 1 cycle of chemotherapy	S, D, and TI	Not known	15	Indeterminate	ND	Cyto	ND	ND	P	Polyclonal	95	Alive, no rebiopsy, no treatment
7	69	F	Recurrent gastric and duodenal ulcers, prior history of H pylori	S, D	Not known	50	P	P	Cyto	P	50-75%	P	Polyclonal	Lost follow-up
8	9	F	Abdominal pain, daily vomit, failure to gain weight since age 6 y (for past 3 y)	S, proximal small intestine	Hyperemia and multiple ulcers in the stomach and multiple ulcers and stenosis in the duodenum	60	P	partial	Partial; cyto	ND	ND	P	ND	47	Subcutaneous methotrexate, healthy
9	38	M	History of PSC, colonoscopy done for PSC work up to rule out IBD	C, TI	Ulcers and papules from ileum to the rectum	30	P	ND	Cyto	ND	75-90%	suboptimal	Restricted	71	Liver transplant for PSC 4 y later. Rebiopsy before the transplant showed persistent disease. On immunosuppression but asymptomatic and PET was negative
10	59	F	Upper GI discomfort, PET SUV 4 of gastric fundus; outside called NK/T-cell lymphoma, consult for HSCT and chemotherapy	S	Ulcer	40	P	P	Cyto	P	25-50%	P	Polyclonal	24	Alive, no rebiopsy or treatment

C, colon; D, duodenum; F, female; M, male; N, negative; ND, not done; P, positive; PSC, primary sclerosing cholangitis; S, stomach; SUV, standardized uptake value; TI, terminal ileum.