Activation scores of dermatological disease pathways, enriched bio-functions, and upstream regulators
| . | . | CTCL/HC D0 . | D10/D0 . | 1m/D0 . | 2m/D0 . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Category . | Disease or bio-function/molecule . | P . | z score median (range) . | P . | z score median (range) . | P . | z score median (range) . | P . | z score median (range) . |
| Diseases | |||||||||
| Dermatological diseases and conditions | Psoriasis | 1.7 × 10−63 | 9.6 × 10−35 | 2.1 × 10−35 | 1.9 × 10−40 | ||||
| Dermatitis | 3.3 × 10−44 | 3.3 × 10−25 | 8.0 × 10−20 | 2.1 × 10−21 | |||||
| Bio-functions | |||||||||
| Cancer | Neoplasia of cells | 9.8 × 10−21 | 3.1 (1.6-4.1) | 2.3 × 10−12 | −0.4 (−4.4 to 1.4) | 2.6 × 10−6 | −0.8 (−4.7 to 0.1) | 3.7 × 10−14 | −2.2 (−4.0 to 2.0) |
| Cellular movement | Migration of cells | 6.7 × 10−61 | 7.0 (3.7-9.6) | 2.6 × 10−31 | −2.7 (−11.3 to 2.4) | 1.7 × 10−14 | −1.2 (−11.7 to 3.8) | 3.2 × 10−28 | −2.9 (−7.3 to 4.0) |
| Leukocyte migration | 9.2 × 10−59 | 6.8 (3.1-8.8) | 8.1 × 10−25 | −2.7 (−9.8 to 3.4) | 3.6 × 10−12 | −1.7 (−9.3 to 4.6) | 2.2 × 10−23 | −2.5 (−7.3 to 2.8) | |
| T-cell migration | 3.2 × 10−27 | 6.2 (4.2-7.0) | 1.4 × 10−23 | −3.1 (−6.4 to 1.5) | 1.8 × 10−15 | −2.0 (−6.5 to 3.4) | 1.4 × 10−15 | −2.3 (−4.9 to 1.8) | |
| Cellular growth | Proliferation of cells | 5.2 × 10−58 | 6.0 (2.3-8.7) | 1.9 × 10−31 | −2.7 (−9.2 to 1.2) | 3.5 × 10−17 | −1.9 (−9.6 to 2.2) | 7.4 × 10−26 | −2.1 (−5.7 to 2.4) |
| Proliferation of immune cells | 2.5 × 10−55 | 3.4 (−0.2 to 4.2) | 3.4 × 10−22 | −1.2 (−4.2 to 1.4) | 2.8 × 10−30 | −0.7 (−4.2 to 2.3) | 2.2 × 10−13 | −0.2 (−2.1 to 0.3) | |
| Proliferation of lymphocytes | 4.1 × 10−55 | 3.2 (−0.2 to 4.3) | 3.4 × 10−24 | −1.1 (−3.5 to 1.5) | 1.2 × 10−15 | −0.4 (−3.6 to 2.5) | 3.1 × 10−13 | −0.5 (−1.9 to 0.2) | |
| Immune cell trafficking | Infiltration by lymphocytes | 5.0 × 10−20 | 1.7 (0.3-3.9) | 2.3 × 10−11 | −1.4 (−1.6 to 1.5) | 1.3 × 10−6 | −1.1 (−2.2 to 1.3) | 1.3 × 10−12 | −1.6 (−3.1 to 0.6) |
| Infiltration by leukocytes | 1.8 × 10−40 | 2.7 (2.2-3.9) | 2.8 × 10−17 | −2.4 (−2.9 to 2.8) | 2.4 × 10−9 | −1.0 (−2.7 to 2.1) | 5.7 × 10−16 | −1.2 (−3.2 to 0.8) | |
| Inflammation | Inflammatory response | 3.5 × 10−36 | 5.6 (2.9-7.9) | 2.1 × 10−22 | −2.3 (−8.7 to 1.8) | 4.3 × 10−10 | −2.3 (−8.3 to 3.7) | 8.8 × 10−17 | −2.7 (−6.7 to 3.3) |
| Upstream regulators | |||||||||
| Transcription factor | STAT3 | 3.6 × 10−48 | 3.8 (2.9-5.8) | 9.8 × 10−189 | −0.9 (−3.8 to 1.7) | 5.6 × 10−16 | −1.1 (−3.0 to 1.7) | 2.0 × 10−23 | −2.1 (−5.2 to 1.6) |
| Cytokine | IL-2 | 4.4 × 10−29 | 7.2 (2.7-9.0) | 5.0 × 10−14 | −3.0 (−9.1 to 3.9) | 1.2 × 10−5 | −1.6 (−9.4 to 6.3) | 1.4 × 10−12 | −2.8 (−7.1 to 1.3) |
| . | . | CTCL/HC D0 . | D10/D0 . | 1m/D0 . | 2m/D0 . | ||||
|---|---|---|---|---|---|---|---|---|---|
| Category . | Disease or bio-function/molecule . | P . | z score median (range) . | P . | z score median (range) . | P . | z score median (range) . | P . | z score median (range) . |
| Diseases | |||||||||
| Dermatological diseases and conditions | Psoriasis | 1.7 × 10−63 | 9.6 × 10−35 | 2.1 × 10−35 | 1.9 × 10−40 | ||||
| Dermatitis | 3.3 × 10−44 | 3.3 × 10−25 | 8.0 × 10−20 | 2.1 × 10−21 | |||||
| Bio-functions | |||||||||
| Cancer | Neoplasia of cells | 9.8 × 10−21 | 3.1 (1.6-4.1) | 2.3 × 10−12 | −0.4 (−4.4 to 1.4) | 2.6 × 10−6 | −0.8 (−4.7 to 0.1) | 3.7 × 10−14 | −2.2 (−4.0 to 2.0) |
| Cellular movement | Migration of cells | 6.7 × 10−61 | 7.0 (3.7-9.6) | 2.6 × 10−31 | −2.7 (−11.3 to 2.4) | 1.7 × 10−14 | −1.2 (−11.7 to 3.8) | 3.2 × 10−28 | −2.9 (−7.3 to 4.0) |
| Leukocyte migration | 9.2 × 10−59 | 6.8 (3.1-8.8) | 8.1 × 10−25 | −2.7 (−9.8 to 3.4) | 3.6 × 10−12 | −1.7 (−9.3 to 4.6) | 2.2 × 10−23 | −2.5 (−7.3 to 2.8) | |
| T-cell migration | 3.2 × 10−27 | 6.2 (4.2-7.0) | 1.4 × 10−23 | −3.1 (−6.4 to 1.5) | 1.8 × 10−15 | −2.0 (−6.5 to 3.4) | 1.4 × 10−15 | −2.3 (−4.9 to 1.8) | |
| Cellular growth | Proliferation of cells | 5.2 × 10−58 | 6.0 (2.3-8.7) | 1.9 × 10−31 | −2.7 (−9.2 to 1.2) | 3.5 × 10−17 | −1.9 (−9.6 to 2.2) | 7.4 × 10−26 | −2.1 (−5.7 to 2.4) |
| Proliferation of immune cells | 2.5 × 10−55 | 3.4 (−0.2 to 4.2) | 3.4 × 10−22 | −1.2 (−4.2 to 1.4) | 2.8 × 10−30 | −0.7 (−4.2 to 2.3) | 2.2 × 10−13 | −0.2 (−2.1 to 0.3) | |
| Proliferation of lymphocytes | 4.1 × 10−55 | 3.2 (−0.2 to 4.3) | 3.4 × 10−24 | −1.1 (−3.5 to 1.5) | 1.2 × 10−15 | −0.4 (−3.6 to 2.5) | 3.1 × 10−13 | −0.5 (−1.9 to 0.2) | |
| Immune cell trafficking | Infiltration by lymphocytes | 5.0 × 10−20 | 1.7 (0.3-3.9) | 2.3 × 10−11 | −1.4 (−1.6 to 1.5) | 1.3 × 10−6 | −1.1 (−2.2 to 1.3) | 1.3 × 10−12 | −1.6 (−3.1 to 0.6) |
| Infiltration by leukocytes | 1.8 × 10−40 | 2.7 (2.2-3.9) | 2.8 × 10−17 | −2.4 (−2.9 to 2.8) | 2.4 × 10−9 | −1.0 (−2.7 to 2.1) | 5.7 × 10−16 | −1.2 (−3.2 to 0.8) | |
| Inflammation | Inflammatory response | 3.5 × 10−36 | 5.6 (2.9-7.9) | 2.1 × 10−22 | −2.3 (−8.7 to 1.8) | 4.3 × 10−10 | −2.3 (−8.3 to 3.7) | 8.8 × 10−17 | −2.7 (−6.7 to 3.3) |
| Upstream regulators | |||||||||
| Transcription factor | STAT3 | 3.6 × 10−48 | 3.8 (2.9-5.8) | 9.8 × 10−189 | −0.9 (−3.8 to 1.7) | 5.6 × 10−16 | −1.1 (−3.0 to 1.7) | 2.0 × 10−23 | −2.1 (−5.2 to 1.6) |
| Cytokine | IL-2 | 4.4 × 10−29 | 7.2 (2.7-9.0) | 5.0 × 10−14 | −3.0 (−9.1 to 3.9) | 1.2 × 10−5 | −1.6 (−9.4 to 6.3) | 1.4 × 10−12 | −2.8 (−7.1 to 1.3) |