Table 3. Immunophenotype of T-PLL and... | American Society of Hematology

Table 3.

Immunophenotype of T-PLL and the most relevant differential diagnosis

Differential diagnosis	Immunophenotype
T-PLL	cyTCL1⁺ (>90%), CD3⁺ (>80%), CD4⁺(60%), CD5⁺ (100%), CD7⁺ (>90%), CD8⁺(15%), CD4⁺CD8⁺(25%)
T-ALL	Tdt ⁺, CD1a⁺
Leukemic PTCL	cyTLC1⁻
T-cell large granular lymphocytic leukemia	CD8⁺, CD57⁺, CD16⁺
Sézary syndrome	CD7⁻, CD4⁺, CD25⁺
Adult T-cell lymphocytic leukemia	CD4⁺, CD25⁺, HTLV1⁺

Differential diagnosis	Immunophenotype
T-PLL	cyTCL1⁺ (>90%), CD3⁺ (>80%), CD4⁺(60%), CD5⁺ (100%), CD7⁺ (>90%), CD8⁺(15%), CD4⁺CD8⁺(25%)
T-ALL	Tdt ⁺, CD1a⁺
Leukemic PTCL	cyTLC1⁻
T-cell large granular lymphocytic leukemia	CD8⁺, CD57⁺, CD16⁺
Sézary syndrome	CD7⁻, CD4⁺, CD25⁺
Adult T-cell lymphocytic leukemia	CD4⁺, CD25⁺, HTLV1⁺

Percentage of patients with T-PLL expressing specific markers.¹⁹