Effect of orally administered AV513 on the cuticle bleeding time in severe hemophilia A dogs
| AV513 dose, mg/kg . | Total CBT score . | ||
|---|---|---|---|
| Bertha . | Darla . | Wembley . | |
| Baseline | 37 | 34 | 59 |
| 5.0 (5 days) | 42 | 56 | 58 |
| 7.5 (7 days) | 23 | 34 | 62 |
| 15.0 (7 days) | 29 | 11* | 44 |
| Wash out (3 weeks) | 49 | 54 | 59 |
| 20.0 (7 days) | 3* | 58 | 2* |
| AV513 dose, mg/kg . | Total CBT score . | ||
|---|---|---|---|
| Bertha . | Darla . | Wembley . | |
| Baseline | 37 | 34 | 59 |
| 5.0 (5 days) | 42 | 56 | 58 |
| 7.5 (7 days) | 23 | 34 | 62 |
| 15.0 (7 days) | 29 | 11* | 44 |
| Wash out (3 weeks) | 49 | 54 | 59 |
| 20.0 (7 days) | 3* | 58 | 2* |
Three treatment-naïve, severe hemophilia A dogs received twice daily the indicated doses of AV513 by mouth for different periods of time. After the last treatment of each regimen, dogs were evaluated for cuticle bleeding time and a total CBT score was assessed.
Within normal range.