Effect of orally administered AV513 on the cuticle bleeding time (CBT) in AAV-FVIII Hemophilia A dogs
| AV513 dose, mg/kg . | Total CBT score . | ||
|---|---|---|---|
| Angus . | Gloria . | Morag . | |
| Baseline | 38 | 54 | 30 |
| 7.5 | 8* | 17 | 47 |
| AV513 dose, mg/kg . | Total CBT score . | ||
|---|---|---|---|
| Angus . | Gloria . | Morag . | |
| Baseline | 38 | 54 | 30 |
| 7.5 | 8* | 17 | 47 |
Three AAV-FVIII dogs received an oral dose of 7.5 mg/kg of AV513 BID for 5 days. After the last dose, the cuticle bleeding time was measured and total CBT score was assessed.
Within normal range.