Effect of subcutaneous injections of AV513 on the cuticle bleeding time in AAV-FVIII hemophilia A dogs
| AV513 dose, mg/kg . | Total CBT score . | ||
|---|---|---|---|
| Angus . | Gloria . | Morag . | |
| Baseline | 36 | 54 | 30 |
| 0.03 | 29 | 48 | 54 |
| 0.1 | 45 | 27 | 48 |
| 0.5 | 33 | 31 | 19 |
| 1.0 | 27 | 7* | 10* |
| 1.5 | 17 | 30 | 30 |
| AV513 dose, mg/kg . | Total CBT score . | ||
|---|---|---|---|
| Angus . | Gloria . | Morag . | |
| Baseline | 36 | 54 | 30 |
| 0.03 | 29 | 48 | 54 |
| 0.1 | 45 | 27 | 48 |
| 0.5 | 33 | 31 | 19 |
| 1.0 | 27 | 7* | 10* |
| 1.5 | 17 | 30 | 30 |
In a dose-escalation study, three AAV-FVIII dogs received different doses of AV513 BID subcutaneously for 5 days. After each dosing period, dogs were evaluated for the cuticle bleeding time as described in “Dog cuticle bleeding time assay.” The number of blood drops/min was converted to a bleeding score and a total bleeding score was calculated for a 15 minute bleeding time evaluation at each time point.
Normal range up to 10.