p53 regulated genes are increased in t(8;21) leukemia samples
| . | Gene name . | AML patient database* . | |
|---|---|---|---|
| Fold change t(8;21)/non-t(8;21) . | P . | ||
| NM_000389 | CDKN1A (p21waf1/cip1) | 1.32 | <.001 |
| NM_004938 | DAPK1 | 1.18 | <.001 |
| NM_001924 | GADD45A | 1.29 | <.05 |
| NM_000201 | ICAM1 | 1.22 | <.05 |
| NM_021127 | PMAIP1 (Noxa) | 2.09 | <.05 |
| NM_004881 | TP53I3 (PIG3) | 1.23 | .062 |
| NM_022470 | WIG1 | 1.03 | NS |
| . | Gene name . | AML patient database* . | |
|---|---|---|---|
| Fold change t(8;21)/non-t(8;21) . | P . | ||
| NM_000389 | CDKN1A (p21waf1/cip1) | 1.32 | <.001 |
| NM_004938 | DAPK1 | 1.18 | <.001 |
| NM_001924 | GADD45A | 1.29 | <.05 |
| NM_000201 | ICAM1 | 1.22 | <.05 |
| NM_021127 | PMAIP1 (Noxa) | 2.09 | <.05 |
| NM_004881 | TP53I3 (PIG3) | 1.23 | .062 |
| NM_022470 | WIG1 | 1.03 | NS |
Seven transcripts that are widely regarded as p53 response genes, and that are also present on the microarray chip used in the pediatric AML study.
t(8;21) patient samples have a significantly increased group mean expression level for the indicated p53 target genes when compared with the combined samples from t(15;17), M7, MLL, and “other.” The published data set from Ross et al38 was used for these analyses, using a Welch 2-sided t test with Benjamini-Hochberg correction for multiple testing to determine significance levels.