MMLV CISs identified in Eedhypo/hypo and wild-type lymphomas
| CIS candidate gene . | Protein family . | Mouse chromosome . | Nb insertions . | Total insertions . | P . | Adjusted P . | Human chromosome . | Human diseases* . | |
|---|---|---|---|---|---|---|---|---|---|
| Eedhypo/hypo . | Wild-type . | ||||||||
| Notch1† | Transmembrane receptor | 2qA3 | 18 | 12 | 30 | .999 | .999 | 9q34.3 | T-ALL |
| Fgfr3‡ | NA/Tyr kinase receptor | 5qB1 | 6 | 9 | 15 | .541 | .965 | 4p16.3 | Multiple myeloma, T lymphoma |
| Pim1 | Ser/Thr kinase | 17qA3.3 | 11 | 3 | 14 | .027 | .545 | 6p21.2 | NHL, DLCL |
| Gadd45g | DNA-damage inducible gene | 13qA5 | 6 | 6 | 12 | .743 | .999 | 9q22.2 | — |
| Prm2‡ | Histone protein | 16qA1 | 5 | 4 | 9 | .999 | .999 | 16p13.13 | — |
| Gfi1 | Zinc finger protein | 5qE5 | 2 | 5 | 7 | .419 | .914 | 1p22.1 | — |
| Myo5b‡ | Myosin protein | 18qE2 | 4 | 3 | 7 | .703 | .999 | 18q21.1 | — |
| Nnp1‡ | Nuclear protein | 10qC1 | 0 | 6 | 6 | .023 | .545 | 21q22.3 | — |
| Jundm2 | Transcription factor | 12qD1 | 2 | 4 | 6 | .668 | .999 | 14q24.3 | — |
| Tmepai | Signal transduction | 2qH4 | 3 | 3 | 6 | .999 | .999 | 20q13.32 | — |
| Myc | Transcription factor | 15qD1 | 2 | 3 | 5 | .999 | .999 | 8q24.21 | Burkitt lymphoma, B-CLL |
| Thy1‡ | Membrane glycoprotein | 9qA5.2 | 1 | 4 | 5 | .350 | .914 | 11q23.3 | — |
| Rai17 | SP-RING Zinc finger protein | 14qA3 | 1 | 4 | 5 | .350 | .914 | 10q22.3 | — |
| Bmi1 | Polycomb protein | 2qA3 | 4 | 0 | 4 | .110 | .755 | 10p12.2 | — |
| Sh2d3c‡ | Signal transduction | 2qB | 0 | 4 | 4 | .110 | .755 | 9q34.11 | — |
| Grap2‡ | Signal transduction | 15qE1 | 1 | 3 | 4 | .999 | .999 | 22q13.1 | — |
| Myst4‡ | Histone acetyltransferase | 14qA2 | 2 | 2 | 4 | .999 | .999 | 10q22.2 | AML |
| Zbtb7b‡ | POZ/Krueppel factor/NA | 3qF1 | 3 | 0 | 3 | .110 | .755 | 1q22 | — |
| Zfpn1a1 | Zinc finger protein | 11qA1 | 3 | 0 | 3 | .110 | .755 | 7p12.2 | ALL, DLBL |
| Brwd2 | WD-repeat protein | 7qF3 | 1 | 2 | 3 | .999 | .999 | 6q14.1 | — |
| Fli1/Ets1 | Transcription factor/transcription factor | 9qA4 | 2 | 0 | 2 | .235 | .914 | 11q24.3 | — |
| Runx3 | Transcription factor | 4qD3 | 2 | 0 | 2 | .235 | .914 | 1p36.11 | — |
| Hirip3‡ | NA | 7qF3 | 0 | 2 | 2 | .490 | .914 | 16p11.2 | — |
| Hhex | Homeobox protein | 19qC2 | 0 | 2 | 2 | .490 | .914 | 10q23.33 | — |
| Idb3/E2F2 | Transcription factor/HLH factor | 4qD3 | 0 | 2 | 2 | .490 | .914 | 1p36.12 | — |
| Lfng | Glycosyltransferase | 5qG2 | 0 | 2 | 2 | .490 | .914 | 7p22.3 | — |
| Pex5 | Peroxisomal targeting signal | 6qF2 | 0 | 2 | 2 | .490 | .914 | 12p13.31 | — |
| Supt4h2/Bzrap1 | Transcription initiation factor/NA | 11qC | 0 | 2 | 2 | .490 | .914 | 17q23.2 | — |
| Eml4 | WD-repeat protein | 17qE4 | 1 | 1 | 2 | .999 | .999 | 2p21 | — |
| Ris2 | DNA replication factor | 8qE1 | 1 | 1 | 2 | .999 | .999 | 16q24.3 | — |
| Supt6h‡ | Transcription initiation factor | 11qB5 | 1 | 1 | 2 | .999 | .999 | 17q11.2 | — |
| Zfp217 | Zinc finger protein | 2qH3 | 1 | 1 | 2 | .999 | .999 | 20q13.2 | — |
| Zfp644‡ | Zinc finger protein | 5qE5 | 1 | 1 | 2 | .999 | .999 | 1qp22.2 | — |
| CIS candidate gene . | Protein family . | Mouse chromosome . | Nb insertions . | Total insertions . | P . | Adjusted P . | Human chromosome . | Human diseases* . | |
|---|---|---|---|---|---|---|---|---|---|
| Eedhypo/hypo . | Wild-type . | ||||||||
| Notch1† | Transmembrane receptor | 2qA3 | 18 | 12 | 30 | .999 | .999 | 9q34.3 | T-ALL |
| Fgfr3‡ | NA/Tyr kinase receptor | 5qB1 | 6 | 9 | 15 | .541 | .965 | 4p16.3 | Multiple myeloma, T lymphoma |
| Pim1 | Ser/Thr kinase | 17qA3.3 | 11 | 3 | 14 | .027 | .545 | 6p21.2 | NHL, DLCL |
| Gadd45g | DNA-damage inducible gene | 13qA5 | 6 | 6 | 12 | .743 | .999 | 9q22.2 | — |
| Prm2‡ | Histone protein | 16qA1 | 5 | 4 | 9 | .999 | .999 | 16p13.13 | — |
| Gfi1 | Zinc finger protein | 5qE5 | 2 | 5 | 7 | .419 | .914 | 1p22.1 | — |
| Myo5b‡ | Myosin protein | 18qE2 | 4 | 3 | 7 | .703 | .999 | 18q21.1 | — |
| Nnp1‡ | Nuclear protein | 10qC1 | 0 | 6 | 6 | .023 | .545 | 21q22.3 | — |
| Jundm2 | Transcription factor | 12qD1 | 2 | 4 | 6 | .668 | .999 | 14q24.3 | — |
| Tmepai | Signal transduction | 2qH4 | 3 | 3 | 6 | .999 | .999 | 20q13.32 | — |
| Myc | Transcription factor | 15qD1 | 2 | 3 | 5 | .999 | .999 | 8q24.21 | Burkitt lymphoma, B-CLL |
| Thy1‡ | Membrane glycoprotein | 9qA5.2 | 1 | 4 | 5 | .350 | .914 | 11q23.3 | — |
| Rai17 | SP-RING Zinc finger protein | 14qA3 | 1 | 4 | 5 | .350 | .914 | 10q22.3 | — |
| Bmi1 | Polycomb protein | 2qA3 | 4 | 0 | 4 | .110 | .755 | 10p12.2 | — |
| Sh2d3c‡ | Signal transduction | 2qB | 0 | 4 | 4 | .110 | .755 | 9q34.11 | — |
| Grap2‡ | Signal transduction | 15qE1 | 1 | 3 | 4 | .999 | .999 | 22q13.1 | — |
| Myst4‡ | Histone acetyltransferase | 14qA2 | 2 | 2 | 4 | .999 | .999 | 10q22.2 | AML |
| Zbtb7b‡ | POZ/Krueppel factor/NA | 3qF1 | 3 | 0 | 3 | .110 | .755 | 1q22 | — |
| Zfpn1a1 | Zinc finger protein | 11qA1 | 3 | 0 | 3 | .110 | .755 | 7p12.2 | ALL, DLBL |
| Brwd2 | WD-repeat protein | 7qF3 | 1 | 2 | 3 | .999 | .999 | 6q14.1 | — |
| Fli1/Ets1 | Transcription factor/transcription factor | 9qA4 | 2 | 0 | 2 | .235 | .914 | 11q24.3 | — |
| Runx3 | Transcription factor | 4qD3 | 2 | 0 | 2 | .235 | .914 | 1p36.11 | — |
| Hirip3‡ | NA | 7qF3 | 0 | 2 | 2 | .490 | .914 | 16p11.2 | — |
| Hhex | Homeobox protein | 19qC2 | 0 | 2 | 2 | .490 | .914 | 10q23.33 | — |
| Idb3/E2F2 | Transcription factor/HLH factor | 4qD3 | 0 | 2 | 2 | .490 | .914 | 1p36.12 | — |
| Lfng | Glycosyltransferase | 5qG2 | 0 | 2 | 2 | .490 | .914 | 7p22.3 | — |
| Pex5 | Peroxisomal targeting signal | 6qF2 | 0 | 2 | 2 | .490 | .914 | 12p13.31 | — |
| Supt4h2/Bzrap1 | Transcription initiation factor/NA | 11qC | 0 | 2 | 2 | .490 | .914 | 17q23.2 | — |
| Eml4 | WD-repeat protein | 17qE4 | 1 | 1 | 2 | .999 | .999 | 2p21 | — |
| Ris2 | DNA replication factor | 8qE1 | 1 | 1 | 2 | .999 | .999 | 16q24.3 | — |
| Supt6h‡ | Transcription initiation factor | 11qB5 | 1 | 1 | 2 | .999 | .999 | 17q11.2 | — |
| Zfp217 | Zinc finger protein | 2qH3 | 1 | 1 | 2 | .999 | .999 | 20q13.2 | — |
| Zfp644‡ | Zinc finger protein | 5qE5 | 1 | 1 | 2 | .999 | .999 | 1qp22.2 | — |
P value is based on the Fisher exact test. Adjusted P value applies the Benjamini-Hochberg correction.
T-ALL indicates T-cell acute lymphoblastic leukemia; NA, not available; NHL, non-Hodgkin leukemia; DLCL, diffuse large-cell leukemia; B-CLL, B-cell chronic lymphocytic leukemia; AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; DLBL, diffuse large B-cell lymphoma; and —, not identified in Human blood diseases.
Genes implicated in human blood diseases according to the Cancer Gene Census (www.sanger.ac.uk/genetics/CGP/Census).
Some tumors contained more than 1 MMLV integration in Notch1. Frequency of tumors with Notch1 MMLV integration: Wild-type, 10 of 26; Eedhypo/hypo, 9 of 25. See Table S2 for details.
New CIS identified in this screen.