Table 1 Survival of Eed mutant and... | American Society of Hematology

Table 1

Survival of Eed mutant and wild-type mice and phenotypic characterization of their lymphomas

Mouse line	Treatment	n	Median survival, d	Penetrance, %	Lymphoma, %			Tumor-free, %*
Mouse line	Treatment	n	Median survival, d	Penetrance, %	B cell	T cell	Not determined	Tumor-free, %*
Wild-type B6	Irradiated	13	504	62	—	23	38	38
Eed^null/+	Irradiated	13	338	92	31	38	23	8
Wild-type 101 × C3Hf	Irradiated	16	> 600	19	—	13	6	81
Eed^hypo/hypo	Irradiated	11	184	73	9	46	18	27
Wild-type 101 × C3Hf	MMLV	27	190	100	19	70	11	—
Eed^hypo/+	MMLV	47	151	100	13	64	23	—
Eed^hypo/hypo	MMLV	30	128	100	9	69	22	—

Mouse line	Treatment	n	Median survival, d	Penetrance, %	Lymphoma, %			Tumor-free, %*
Mouse line	Treatment	n	Median survival, d	Penetrance, %	B cell	T cell	Not determined	Tumor-free, %*
Wild-type B6	Irradiated	13	504	62	—	23	38	38
Eed^null/+	Irradiated	13	338	92	31	38	23	8
Wild-type 101 × C3Hf	Irradiated	16	> 600	19	—	13	6	81
Eed^hypo/hypo	Irradiated	11	184	73	9	46	18	27
Wild-type 101 × C3Hf	MMLV	27	190	100	19	70	11	—
Eed^hypo/+	MMLV	47	151	100	13	64	23	—
Eed^hypo/hypo	MMLV	30	128	100	9	69	22	—

Penetrance is equal to 100% minus the percentage of mice that died of nonhematologic etiology. B cell indicates B-ALL; T cell, T-ALL; Not determined, lymphoma cell type not determined; and —, not applicable.

*Tumor-free mice were killed at 600 days.

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