Comparison of the clinical characteristics of patients who developed Gram-negative bacteremia with patients who did not develop bacteremia
| Clinical variable . | Univariate analysis . | Multivariate analysis . | |||
|---|---|---|---|---|---|
| Controls, N = 865 . | Cases, N = 350 . | P . | Odds ratio (95% CI) . | P . | |
| Age, y | 34.0 ± 15.2 | 34.1 ± 15.9 | .95 | — | — |
| Sex match (patient/donor) | |||||
| Male/male | 305 (35) | 109 (31) | .024 | Referent | — |
| Male/female | 196 (23) | 72 (21) | — | 0.95 (0.65-1.40) | .791 |
| Female/male | 194 (22) | 108 (31) | — | 1.51 (1.06-2.16) | .023 |
| Female/female | 169 (20) | 61 (17) | — | 1.01 (0.67-1.50) | .977 |
| Race match (patient/donor) | |||||
| White/white | 765 (88) | 294 (84) | .105 | — | — |
| White/nonwhite | 7 (1) | 4 (1) | — | — | — |
| Nonwhite/white | 8 (1) | 8 (2) | — | — | — |
| Nonwhite/nonwhite | 85 (10) | 44 (13) | — | — | — |
| Disease risk | |||||
| Low | 298 (35) | 93 (26) | .015 | Referent | — |
| Moderate | 237 (27) | 97 (28) | — | 0.99 (0.68-1.45) | .974 |
| High | 330 (38) | 160 (46) | — | 1.43 (1.00-2.04) | .049 |
| Donor type | |||||
| Matched related | 452 (52) | 156 (45) | .043 | — | — |
| Mismatched related | 103 (12) | 53 (15) | — | — | — |
| Unrelated | 310 (36) | 141 (40) | — | — | — |
| Total body irradiation | |||||
| No | 335 (39) | 84 (24) | <.001 | Referent | — |
| Yes | 530 (61) | 266 (76) | — | 1.50 (1.08-2.07) | .015 |
| Stem cell source | |||||
| Bone marrow | 762 (88) | 326 (93) | .024 | — | — |
| PBSC | 96 (11) | 21 (6) | — | — | — |
| Other | 7 (1) | 3 (1) | — | — | — |
| CMV serostatus (patient/donor) | |||||
| Negative/negative | 397 (46) | 100 (29) | <.001 | Referent | — |
| Negative/positive | 152 (18) | 54 (15) | — | 1.39 (0.93-2.09) | .113 |
| Positive/negative | 125 (14) | 91 (26) | — | 2.59 (1.77-3.81) | <.001 |
| Positive/positive | 188 (22) | 104 (30) | — | 2.57 (1.78-3.69) | <.001 |
| Pretransplant neutropenia | |||||
| No | 441 (51) | 132 (38) | <.001 | Referent | — |
| Yes | 424 (49) | 218 (62) | — | 1.37 (1.01-1.87) | .045 |
| Days to engraftment | 20.5 ± 5.2 | 20.0 ± 5.8 | .127 | — | — |
| Neutropenia after initial engraftment | |||||
| No | 783 (91) | 246 (70) | <.001 | Referent | — |
| Yes | 82 (9) | 104 (30) | — | 2.77 (1.95-3.95) | <.001 |
| Acute GVHD | |||||
| No | 334 (39) | 55 (16) | <.001 | Referent | — |
| Yes | 518 (61) | 292 (84) | — | 3.03 (2.14-4.27) | <.001 |
| Chronic GVHD | |||||
| No | 574 (67) | 183 (55) | <.001 | Referent | — |
| Yes | 284 (33) | 155 (45) | — | 1.66 (1.24-2.22) | .001 |
| Clinical variable . | Univariate analysis . | Multivariate analysis . | |||
|---|---|---|---|---|---|
| Controls, N = 865 . | Cases, N = 350 . | P . | Odds ratio (95% CI) . | P . | |
| Age, y | 34.0 ± 15.2 | 34.1 ± 15.9 | .95 | — | — |
| Sex match (patient/donor) | |||||
| Male/male | 305 (35) | 109 (31) | .024 | Referent | — |
| Male/female | 196 (23) | 72 (21) | — | 0.95 (0.65-1.40) | .791 |
| Female/male | 194 (22) | 108 (31) | — | 1.51 (1.06-2.16) | .023 |
| Female/female | 169 (20) | 61 (17) | — | 1.01 (0.67-1.50) | .977 |
| Race match (patient/donor) | |||||
| White/white | 765 (88) | 294 (84) | .105 | — | — |
| White/nonwhite | 7 (1) | 4 (1) | — | — | — |
| Nonwhite/white | 8 (1) | 8 (2) | — | — | — |
| Nonwhite/nonwhite | 85 (10) | 44 (13) | — | — | — |
| Disease risk | |||||
| Low | 298 (35) | 93 (26) | .015 | Referent | — |
| Moderate | 237 (27) | 97 (28) | — | 0.99 (0.68-1.45) | .974 |
| High | 330 (38) | 160 (46) | — | 1.43 (1.00-2.04) | .049 |
| Donor type | |||||
| Matched related | 452 (52) | 156 (45) | .043 | — | — |
| Mismatched related | 103 (12) | 53 (15) | — | — | — |
| Unrelated | 310 (36) | 141 (40) | — | — | — |
| Total body irradiation | |||||
| No | 335 (39) | 84 (24) | <.001 | Referent | — |
| Yes | 530 (61) | 266 (76) | — | 1.50 (1.08-2.07) | .015 |
| Stem cell source | |||||
| Bone marrow | 762 (88) | 326 (93) | .024 | — | — |
| PBSC | 96 (11) | 21 (6) | — | — | — |
| Other | 7 (1) | 3 (1) | — | — | — |
| CMV serostatus (patient/donor) | |||||
| Negative/negative | 397 (46) | 100 (29) | <.001 | Referent | — |
| Negative/positive | 152 (18) | 54 (15) | — | 1.39 (0.93-2.09) | .113 |
| Positive/negative | 125 (14) | 91 (26) | — | 2.59 (1.77-3.81) | <.001 |
| Positive/positive | 188 (22) | 104 (30) | — | 2.57 (1.78-3.69) | <.001 |
| Pretransplant neutropenia | |||||
| No | 441 (51) | 132 (38) | <.001 | Referent | — |
| Yes | 424 (49) | 218 (62) | — | 1.37 (1.01-1.87) | .045 |
| Days to engraftment | 20.5 ± 5.2 | 20.0 ± 5.8 | .127 | — | — |
| Neutropenia after initial engraftment | |||||
| No | 783 (91) | 246 (70) | <.001 | Referent | — |
| Yes | 82 (9) | 104 (30) | — | 2.77 (1.95-3.95) | <.001 |
| Acute GVHD | |||||
| No | 334 (39) | 55 (16) | <.001 | Referent | — |
| Yes | 518 (61) | 292 (84) | — | 3.03 (2.14-4.27) | <.001 |
| Chronic GVHD | |||||
| No | 574 (67) | 183 (55) | <.001 | Referent | — |
| Yes | 284 (33) | 155 (45) | — | 1.66 (1.24-2.22) | .001 |
Data entries are numbers (%) for each item.
CI indicates confidence interval; PBSC, peripheral blood stem cell; CMV, cytomegalovirus; GVHD, graft-versus-host disease; and —, not applicable.