Recurrent genetic abnormalities detected by SNP-chip
| Chromosomal sites . | Type of abnormality . | No. of cases (%) . | Candidate genes . |
|---|---|---|---|
| 1q | Duplication | 44 (11) | — |
| 1q | Deletion | 11 (3) | — |
| 3p21 | Deletion | 6 (2) | — |
| 3p14.2 | Deletion | 6 (2) | FHIT |
| 3q26.3 | Deletion | 10 (3) | TBL1XR1 |
| 4q31 | Deletion | 7 (2) | — |
| 6q | Deletion | 46 (11) | — |
| 7p | Deletion | 10 (3) | — |
| 7q34 | Deletion | 7 (2) | — |
| 8p | Deletion | 13 (3) | — |
| 8q | Duplication | 9 (2) | — |
| 9q | Dup/amp | 9 (2) | ABL |
| 10p | Duplication | 7 (2) | — |
| 10q24 | Deletion | 12 (3) | — |
| 11q | Deletion | 24 (6) | — |
| 12p | Duplication | 13 (3) | — |
| 13q14.2 | Deletion | 14 (4) | RB1 |
| 15q | Deletion | 7 (2) | — |
| 17p | Deletion | 8 (2) | TP53 |
| 17q | Duplication | 10 (3) | — |
| 17q11.2 | Deletion | 7 (2) | NF1 |
| 20p12.2 | Deletion | 6 (2) | — |
| 20q | Deletion | 13 (3) | — |
| Xp21.2 | Deletion | 8 (2) | DMD |
| Gain of Chr. 21 or 21q in non-HD ALL cases | — | 37/283 (13) | — |
| Gain of Chr. X or Xq in non-HD ALL cases | — | 23/283 (8) | — |
| Chromosomal sites . | Type of abnormality . | No. of cases (%) . | Candidate genes . |
|---|---|---|---|
| 1q | Duplication | 44 (11) | — |
| 1q | Deletion | 11 (3) | — |
| 3p21 | Deletion | 6 (2) | — |
| 3p14.2 | Deletion | 6 (2) | FHIT |
| 3q26.3 | Deletion | 10 (3) | TBL1XR1 |
| 4q31 | Deletion | 7 (2) | — |
| 6q | Deletion | 46 (11) | — |
| 7p | Deletion | 10 (3) | — |
| 7q34 | Deletion | 7 (2) | — |
| 8p | Deletion | 13 (3) | — |
| 8q | Duplication | 9 (2) | — |
| 9q | Dup/amp | 9 (2) | ABL |
| 10p | Duplication | 7 (2) | — |
| 10q24 | Deletion | 12 (3) | — |
| 11q | Deletion | 24 (6) | — |
| 12p | Duplication | 13 (3) | — |
| 13q14.2 | Deletion | 14 (4) | RB1 |
| 15q | Deletion | 7 (2) | — |
| 17p | Deletion | 8 (2) | TP53 |
| 17q | Duplication | 10 (3) | — |
| 17q11.2 | Deletion | 7 (2) | NF1 |
| 20p12.2 | Deletion | 6 (2) | — |
| 20q | Deletion | 13 (3) | — |
| Xp21.2 | Deletion | 8 (2) | DMD |
| Gain of Chr. 21 or 21q in non-HD ALL cases | — | 37/283 (13) | — |
| Gain of Chr. X or Xq in non-HD ALL cases | — | 23/283 (8) | — |
Nonrandom chromosomal abnormalities (frequency >1.5% of all cases) are listed. 9p deletion and 12p deletions are separately shown in Figure 2B.
HD indicates hyperdiploid (>50 chromosomes); dup/amp, duplication and amplification of the region; and —, not applicable.