Table 1 L1cre ( ); Alk1 3loxp/3loxP... | American Society of Hematology

Table 1

L1cre (+); Alk1^3loxp/3loxP fetuses resulted in embryonic lethality at late gestational stages

Cross*	Stage	Progeny, total no.	Mutants [L1cre(+);Alk1^3loxP/3loxP], no.	Embryos exhibiting phenotype* among the mutants, no.	Embryos found dead among the mutants, no.
L1cre(+); Alk1^+/3loxP	E14.5	13	4	4†	0
× Alk1^3loxP/3loxP or	E15.5	24	10	10	0
Alk1^+/3loxP	E16.5	91	17	14	3
	E17.5	78	9	3	6
	E18.5	22	8	0	8

Cross*	Stage	Progeny, total no.	Mutants [L1cre(+);Alk1^3loxP/3loxP], no.	Embryos exhibiting phenotype* among the mutants, no.	Embryos found dead among the mutants, no.
L1cre(+); Alk1^+/3loxP	E14.5	13	4	4†	0
× Alk1^3loxP/3loxP or	E15.5	24	10	10	0
Alk1^+/3loxP	E16.5	91	17	14	3
	E17.5	78	9	3	6
	E18.5	22	8	0	8

Phenotype in L1cre(+);Alk1^3loxP/3loxP refers to the bulged yolk sac blood vessels similar to those in Figure 4B.

The mutant yolk sac vessels looked enlarged, but not as distinctive as the ones in E15.5 and later stages.