Effect of PPARγ ligands on IL-6 release from HS-5 cells stimulated by different MM cell lines
| Cells . | IL-6 production, ng/mL . | |||
|---|---|---|---|---|
| Control . | 15-d-PGJ2 . | Troglitazone . | Wy14643 . | |
| HS-5 alone | 290.51 ± 19.38 | 235.84 ± 22.50 | 258.66 ± 21.42 | 270.67 ± 27.80 |
| HS-5 + KAS6/1 | 403.86 ± 36.49 | 134.72 ± 41.06* | 94.58 ± 6.02* | 363.14 ± 96.46 |
| HS-5 + ANBL-6 | 358.94 ± 61.28 | 130.33 ± 29.67* | 90.98 ± 10.05* | 358.74 ± 57.63 |
| Cells . | IL-6 production, ng/mL . | |||
|---|---|---|---|---|
| Control . | 15-d-PGJ2 . | Troglitazone . | Wy14643 . | |
| HS-5 alone | 290.51 ± 19.38 | 235.84 ± 22.50 | 258.66 ± 21.42 | 270.67 ± 27.80 |
| HS-5 + KAS6/1 | 403.86 ± 36.49 | 134.72 ± 41.06* | 94.58 ± 6.02* | 363.14 ± 96.46 |
| HS-5 + ANBL-6 | 358.94 ± 61.28 | 130.33 ± 29.67* | 90.98 ± 10.05* | 358.74 ± 57.63 |
HS-5 cells were cocultured with KAS6/1 or ANBL-6 cells and treated with 1 μM 15-d-PGJ2, 10 μM troglitazone, or 50 μM Wy14643 for 48 hours. IL-6 concentration was determined in supernatants. Values represent the mean plus or minus SE from 3 independent experiments (*P < .05, compared with control group). IL-6 concentration was not detectable in KAS6/1 or ANBL-6 cells alone.