Logistic regression models for grades II-IV and grades III-IV acute GVHD and Cox regression models for relapse and overall mortality
| . | Unadjusted models . | Adjusted models . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grades 2-4 aGVHD . | Grades 3-4 aGVHD . | Relapse . | Overall mortality . | Grades 2-4 aGVHD . | Grades 3-4 aGVHD . | Relapse . | Overall mortality . | |
| Matched at HLA-DPB1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Mismatched at HLA-DPB1 | 1.33 (1.17-1.50; P < .001) | 1.26 (1.10-1.45; P < .001) | 0.82 (0.70-0.96; P = .01) | 1.15 (1.05-1.27; P = .003) | 1.33 (1.18-1.51; P < .001) | 1.22 (1.06-1.40; P = .005) | 0.78 (0.67-0.92; P = .002) | 1.09 (0.99-1.19; P = .07) |
| 1 allele mismatched | 1.30 (1.14-1.48; P = .001) | 1.21 (1.04-1.40; P = .01) | 0.82 (0.70-0.96; P = .01) | 1.14 (1.03-1.25; P = .01) | 1.31 (1.14-1.49; P < .001) | 1.18 (1.02-1.37; P = .03) | 0.79 (0.67-0.93; P = .005) | 1.08 (0.98-1.19; P = .13) |
| 2 alleles mismatched | 1.37 (1.19-1.58; P < .001) | 1.34 (1.15-1.57; P < .001) | 0.82 (0.69-0.98; P = .03) | 1.18 (1.07-1.31; P = .002) | 1.36 (1.18-1.58; P < .001) | 1.27 (1.09-1.49; P = .003) | 0.76 (0.64-0.91; P = .003) | 1.09 (0.98-1.21; P = .11) |
| . | Unadjusted models . | Adjusted models . | ||||||
|---|---|---|---|---|---|---|---|---|
| Grades 2-4 aGVHD . | Grades 3-4 aGVHD . | Relapse . | Overall mortality . | Grades 2-4 aGVHD . | Grades 3-4 aGVHD . | Relapse . | Overall mortality . | |
| Matched at HLA-DPB1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Mismatched at HLA-DPB1 | 1.33 (1.17-1.50; P < .001) | 1.26 (1.10-1.45; P < .001) | 0.82 (0.70-0.96; P = .01) | 1.15 (1.05-1.27; P = .003) | 1.33 (1.18-1.51; P < .001) | 1.22 (1.06-1.40; P = .005) | 0.78 (0.67-0.92; P = .002) | 1.09 (0.99-1.19; P = .07) |
| 1 allele mismatched | 1.30 (1.14-1.48; P = .001) | 1.21 (1.04-1.40; P = .01) | 0.82 (0.70-0.96; P = .01) | 1.14 (1.03-1.25; P = .01) | 1.31 (1.14-1.49; P < .001) | 1.18 (1.02-1.37; P = .03) | 0.79 (0.67-0.93; P = .005) | 1.08 (0.98-1.19; P = .13) |
| 2 alleles mismatched | 1.37 (1.19-1.58; P < .001) | 1.34 (1.15-1.57; P < .001) | 0.82 (0.69-0.98; P = .03) | 1.18 (1.07-1.31; P = .002) | 1.36 (1.18-1.58; P < .001) | 1.27 (1.09-1.49; P = .003) | 0.76 (0.64-0.91; P = .003) | 1.09 (0.98-1.21; P = .11) |
Adjusted models include severity of disease; patient age at transplantation; number of mismatched alleles at HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1; patient/donor sex; patient/donor CMV status; source of stem cells; and use of T-cell depletion.
Ranges in parentheses are 95% CI.