CC-122-ST-001 Part A
| Subjects with a treatment emergent adverse event (AE) by preferred term(1) . | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Dose in mg | 0.5 | 1 | 1.5 | 2 | 2.5 | 3 | 3.5 | Overall | Overall |
| Subjects | n=3 | n=4 | n=3 | n=3 | n=6 | n=8 | n=7 | n=34 | % |
| AE | |||||||||
| Fatigue | 2 | 3 | 2 | 1 | 2 | 3 | 4 | 17 | 50 |
| Neutropenia | 0 | 2 | 1 | 1 | 2 | 3 | 1 | 10 | 29.4 |
| Asthenia | 0 | 1 | 0 | 0 | 1 | 1 | 4 | 7 | 20.6 |
| Constipation | 2 | 1 | 2 | 0 | 0 | 0 | 2 | 7 | 20.6 |
| Nausea | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 7 | 20.6 |
| Dyspnea | 0 | 1 | 0 | 0 | 0 | 3 | 2 | 6 | 17.6 |
| Vomiting | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 6 | 17.6 |
| Anemia | 0 | 2 | 0 | 0 | 1 | 2 | 0 | 5 | 14.7 |
| Decreased Appetite | 3 | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 14.7 |
| Diarrhea | 0 | 1 | 1 | 0 | 1 | 0 | 2 | 5 | 14.7 |
| Dizziness | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 5 | 14.7 |
| Pruritis | 0 | 0 | 0 | 2 | 0 | 1 | 2 | 5 | 14.7 |
| Pyrexia | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 5 | 14.7 |
| Alopecia | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 4 | 11.8 |
| Cough | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 4 | 11.8 |
| Headache | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 4 | 11.8 |
| Edema Peripheral | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 4 | 11.8 |
| Tumor Pain | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4 | 11.8 |
| Urinary Tract Infection | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 4 | 11.8 |
| Subjects with a treatment emergent adverse event (AE) by preferred term(1) . | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Dose in mg | 0.5 | 1 | 1.5 | 2 | 2.5 | 3 | 3.5 | Overall | Overall |
| Subjects | n=3 | n=4 | n=3 | n=3 | n=6 | n=8 | n=7 | n=34 | % |
| AE | |||||||||
| Fatigue | 2 | 3 | 2 | 1 | 2 | 3 | 4 | 17 | 50 |
| Neutropenia | 0 | 2 | 1 | 1 | 2 | 3 | 1 | 10 | 29.4 |
| Asthenia | 0 | 1 | 0 | 0 | 1 | 1 | 4 | 7 | 20.6 |
| Constipation | 2 | 1 | 2 | 0 | 0 | 0 | 2 | 7 | 20.6 |
| Nausea | 1 | 1 | 1 | 1 | 0 | 2 | 1 | 7 | 20.6 |
| Dyspnea | 0 | 1 | 0 | 0 | 0 | 3 | 2 | 6 | 17.6 |
| Vomiting | 1 | 1 | 1 | 1 | 0 | 2 | 0 | 6 | 17.6 |
| Anemia | 0 | 2 | 0 | 0 | 1 | 2 | 0 | 5 | 14.7 |
| Decreased Appetite | 3 | 0 | 0 | 0 | 0 | 1 | 1 | 5 | 14.7 |
| Diarrhea | 0 | 1 | 1 | 0 | 1 | 0 | 2 | 5 | 14.7 |
| Dizziness | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 5 | 14.7 |
| Pruritis | 0 | 0 | 0 | 2 | 0 | 1 | 2 | 5 | 14.7 |
| Pyrexia | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 5 | 14.7 |
| Alopecia | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 4 | 11.8 |
| Cough | 1 | 0 | 1 | 0 | 0 | 2 | 0 | 4 | 11.8 |
| Headache | 0 | 1 | 0 | 2 | 0 | 0 | 1 | 4 | 11.8 |
| Edema Peripheral | 0 | 0 | 0 | 0 | 1 | 0 | 3 | 4 | 11.8 |
| Tumor Pain | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4 | 11.8 |
| Urinary Tract Infection | 1 | 2 | 0 | 0 | 1 | 0 | 0 | 4 | 11.8 |