Table 2. Recommended dosing of UFH and... | American Society of Hematology

Table 2.

Recommended dosing of UFH and LMWH in neonates and children.

UFH i.v.	Neonates < 5kg	Children > 5kg	Target aPTT at 4h
* 1 mg Enoxaparin = 110 anti-FXa units
For UFH: aPTT 4 hours after loading dose and 4 hours after each dosage adjustment, at least once daily; keep AT level within normal range; daily blood count (platelets!). For LMWH: anti-FX activity 4 hours after injection
loading dose	1 × 75 U/kg/10 min	1 × 75 U/kg/10 min
maintenance	25–30 U/kg/h	20 U/kg/h	60–85 sec.
LMWH s.c.	Neonates < 5kg	Children > 5kg	Target anti-FXa at 4 h
initial treatment dose
Enoxaparin*	1 × 2.0 mg/kg/d	1 × 1.5 mg/kg/d	0.4–0.8 U/mL
Dalteparin	1 × 200 U/kg/d	1 × 150 U/kg/d	0.4–0.8 U/mL
Reviparin	2 × 150 U/kg/d	2 × 100 U/kg/d	0.5–1.0 U/mL
initial prophylactic dose
Enoxaparin*	1 × 1.5 mg/kg/d	1 × 1.0 mg/kg/d	< 0.4 U/mL
Dalteparin	1 × 100 U/kg/d	1 × 50 U/kg/d	< 0.4 U/mL
Reviparin	2 × 50 U/kg/d	2 × 30 U/kg/d	< 0.5 U/mL

UFH i.v.	Neonates < 5kg	Children > 5kg	Target aPTT at 4h
* 1 mg Enoxaparin = 110 anti-FXa units
For UFH: aPTT 4 hours after loading dose and 4 hours after each dosage adjustment, at least once daily; keep AT level within normal range; daily blood count (platelets!). For LMWH: anti-FX activity 4 hours after injection
loading dose	1 × 75 U/kg/10 min	1 × 75 U/kg/10 min
maintenance	25–30 U/kg/h	20 U/kg/h	60–85 sec.
LMWH s.c.	Neonates < 5kg	Children > 5kg	Target anti-FXa at 4 h
initial treatment dose
Enoxaparin*	1 × 2.0 mg/kg/d	1 × 1.5 mg/kg/d	0.4–0.8 U/mL
Dalteparin	1 × 200 U/kg/d	1 × 150 U/kg/d	0.4–0.8 U/mL
Reviparin	2 × 150 U/kg/d	2 × 100 U/kg/d	0.5–1.0 U/mL
initial prophylactic dose
Enoxaparin*	1 × 1.5 mg/kg/d	1 × 1.0 mg/kg/d	< 0.4 U/mL
Dalteparin	1 × 100 U/kg/d	1 × 50 U/kg/d	< 0.4 U/mL
Reviparin	2 × 50 U/kg/d	2 × 30 U/kg/d	< 0.5 U/mL