Suggested role for stem cell transplantation (SCT) in noncutaneous, mature T/NK neoplasms.
| Disease . | Type and Timing of SCT . |
|---|---|
| *4 prognostic factors in PTCL: age, performance status, LDH and bone marrow involvement (alloSCT will need to be considered in the latter). Group 3 had 2 or more factors and group 4 had 3 or 4 factors.12 | |
| ** Because 5-year survival > 60% has been observed in PTCL/ U only with IPI ≤ 1, early SCT should be investigated in PTCL/U with IPI ≥ 2. | |
| Anaplastic large cell, ALK-positive | Auto – after relapse |
| Anaplastic large cell, ALK-negativ | Auto – if IPI ≥ 3 or ≥ group 3* |
| e | |
| Angioimmunoblastic | Auto – if IPI ≥ 3 or ≥ group 3 |
| PTCL, unspecified | Auto – if IPI ≥ 3** or ≥ group 3 |
| Nasal, localized | Auto – after relapse |
| disseminated | Auto or allo |
| Enteropathy associated | Auto |
| Subcutaneous panniculitis-like | Auto if hemophagocytosis |
| Hepatosplenic, γδ | Allo over auto |
| T prolymphocytic leukemia | Allo over auto |
| Adult T cell leukemia/lymphoma | Allo over auto |
| Aggressive NK leukemia | Allo |
| Disease . | Type and Timing of SCT . |
|---|---|
| *4 prognostic factors in PTCL: age, performance status, LDH and bone marrow involvement (alloSCT will need to be considered in the latter). Group 3 had 2 or more factors and group 4 had 3 or 4 factors.12 | |
| ** Because 5-year survival > 60% has been observed in PTCL/ U only with IPI ≤ 1, early SCT should be investigated in PTCL/U with IPI ≥ 2. | |
| Anaplastic large cell, ALK-positive | Auto – after relapse |
| Anaplastic large cell, ALK-negativ | Auto – if IPI ≥ 3 or ≥ group 3* |
| e | |
| Angioimmunoblastic | Auto – if IPI ≥ 3 or ≥ group 3 |
| PTCL, unspecified | Auto – if IPI ≥ 3** or ≥ group 3 |
| Nasal, localized | Auto – after relapse |
| disseminated | Auto or allo |
| Enteropathy associated | Auto |
| Subcutaneous panniculitis-like | Auto if hemophagocytosis |
| Hepatosplenic, γδ | Allo over auto |
| T prolymphocytic leukemia | Allo over auto |
| Adult T cell leukemia/lymphoma | Allo over auto |
| Aggressive NK leukemia | Allo |