Factors influencing the risk of heparin-induced thrombocytopenia (HIT): type of heparin, type of patient population, and gender (fixed-effects statistical analysis).
| Group (number of studies) . | Common OR for HIT . | 95% CI Common OR . | P-value . | |
|---|---|---|---|---|
| * Studies were pooled across patient type to produce a simple 2 × 2 table; surgical (42/1999) and medical (25/3811), Fisher’s exact test (2-sided) p-value | ||||
| ** Male/surgical and male/medical not considered due to lack of events. | ||||
| Reprinted, with permission.7 | ||||
| Lower | Upper | |||
| Overall effect of heparin type: UFH vs LMHW (7) | 5.29 | 2.84 | 9.86 | < 0.0001 |
| Overall effect of patient type: surgical vs medical (7)* | 3.25 | 1.98 | 5.35 | < 0.0001 |
| Overall effect of gender: female vs male (7) | 2.37 | 1.37 | 4.09 | 0.0015 |
| Studies of interactions of gender (females, males), patient type (surgical, medical), or both (female/surgical; female/medical) on risk of HIT for UFH vs LMWH** | Common OR for HIT: UFH vs LMWH | |||
| Female (7) | 9.22 | 3.87 | 21.97 | < 0.0001 |
| Male (7)* | 1.83 | 0.64 | 5.23 | 0.2907 |
| Comparison of the treatment effect of heparin type in females versus the treatment effect in males, P = 0.0199 | ||||
| Surgical (4) | 13.93 | 4.33 | 44.76 | < 0.0001 |
| Medical (3) | 1.75 | 0.73 | 4.22 | 0.2327 |
| Comparison of the treatment effect of heparin type in surgical versus the treatment effect in medical patients, P = 0.0054 | ||||
| Female/Surgical (4) | 17.39 | 4.22 | 71.70 | < 0.0001 |
| Female/Medical (3) | 3.75 | 1.16 | 12.17 | 0.0252 |
| Comparison of the treatment effect of heparin type in female surgical patients versus the treatment effect in female medical patients, P = 0.1028 | ||||
| Group (number of studies) . | Common OR for HIT . | 95% CI Common OR . | P-value . | |
|---|---|---|---|---|
| * Studies were pooled across patient type to produce a simple 2 × 2 table; surgical (42/1999) and medical (25/3811), Fisher’s exact test (2-sided) p-value | ||||
| ** Male/surgical and male/medical not considered due to lack of events. | ||||
| Reprinted, with permission.7 | ||||
| Lower | Upper | |||
| Overall effect of heparin type: UFH vs LMHW (7) | 5.29 | 2.84 | 9.86 | < 0.0001 |
| Overall effect of patient type: surgical vs medical (7)* | 3.25 | 1.98 | 5.35 | < 0.0001 |
| Overall effect of gender: female vs male (7) | 2.37 | 1.37 | 4.09 | 0.0015 |
| Studies of interactions of gender (females, males), patient type (surgical, medical), or both (female/surgical; female/medical) on risk of HIT for UFH vs LMWH** | Common OR for HIT: UFH vs LMWH | |||
| Female (7) | 9.22 | 3.87 | 21.97 | < 0.0001 |
| Male (7)* | 1.83 | 0.64 | 5.23 | 0.2907 |
| Comparison of the treatment effect of heparin type in females versus the treatment effect in males, P = 0.0199 | ||||
| Surgical (4) | 13.93 | 4.33 | 44.76 | < 0.0001 |
| Medical (3) | 1.75 | 0.73 | 4.22 | 0.2327 |
| Comparison of the treatment effect of heparin type in surgical versus the treatment effect in medical patients, P = 0.0054 | ||||
| Female/Surgical (4) | 17.39 | 4.22 | 71.70 | < 0.0001 |
| Female/Medical (3) | 3.75 | 1.16 | 12.17 | 0.0252 |
| Comparison of the treatment effect of heparin type in female surgical patients versus the treatment effect in female medical patients, P = 0.1028 | ||||