Limitations of vitamin K antagonists.
| Limitation . | Consequence . |
|---|---|
| Slow onset of action | Overlap with a parenteral anticoagulant |
| Genetic variation in metabolism | Variable dose requirements |
| Multiple food and drug interactions | Frequent coagulation monitoring (INR) |
| Narrow therapeutic index | Frequent coagulation monitoring (INR) |
| Limitation . | Consequence . |
|---|---|
| Slow onset of action | Overlap with a parenteral anticoagulant |
| Genetic variation in metabolism | Variable dose requirements |
| Multiple food and drug interactions | Frequent coagulation monitoring (INR) |
| Narrow therapeutic index | Frequent coagulation monitoring (INR) |