Cold hemolytic syndromes.
| Disease . | Antibody . | Coombs . | Specificity . | Course . |
|---|---|---|---|---|
| Abbreviations: BA, blood antigen | ||||
| Paroxysmal cold hemoglobinuria | Donath-Landsteiner IgG | ± | BA P | Acute |
| Cold hemagglutinin disease | Monoclonal IgMκ | +++ | BA I | Chronic |
| Childhood cold agglutinin | Polyclonal IgM | +++ | BA i | Self-limited |
| Disease . | Antibody . | Coombs . | Specificity . | Course . |
|---|---|---|---|---|
| Abbreviations: BA, blood antigen | ||||
| Paroxysmal cold hemoglobinuria | Donath-Landsteiner IgG | ± | BA P | Acute |
| Cold hemagglutinin disease | Monoclonal IgMκ | +++ | BA I | Chronic |
| Childhood cold agglutinin | Polyclonal IgM | +++ | BA i | Self-limited |