Properties of randomized trials testing chemotherapy alone in patients with limited stage Hodgkin lymphoma.
| Author/Reference . | Chemotherapy/Efficacy Equivalence to ABVD . | Radiation Therapy/Part of Combined Modality Therapy . | Sample Size/Power to Detect Important Differences . | Other . |
|---|---|---|---|---|
| Abbreviations: MOPP, nitrogen mustard, Oncovin® (vincristine), prednisone, procarbazine; CVPP, cyclophosphamide, vinblastine, prednisone, procarbazine; EBVP, epirubicin, bleomycin, vinblastine, prednisone; COPP, cyclophosphamide, Oncovin® (vincristine), prednisone, procarbazine; ABVD, doxorubicin (Adriamycin®), bleomycin, vinblastine and dacarbazine; (S)TNI, (sub) total nodal irradiation; IF, involved field; EF, extended field | ||||
| Longo16 | MOPP / no | STNI or TNI / no | 106 / no | Includes Stages I–IIIA, I–IIB and patients with bulky disease |
| Biti17 | MOPP / no | EF / no | 99 / no | |
| Pavlovsky18 | CVPP / no | IF / yes | 277 / yes | Includes Stages I–IIA+B and patients with bulky disease |
| Noordijk14 | EBVP / no | IF / yes | 619 / yes | |
| Laskar19 | ABVD / yes | Predominantly IF / yes | 99 / no | Subset analysis |
| Nachman20 | COPP-ABV / yes | IF / yes | 215 / uncertain | Subset analysis; included pediatric patients only |
| Straus21 | ABVD / yes | EF (n = 54) and IF (n = 11) in an “as treated” analysis / yes | 152 / no | Includes Stages I–IIIA and I–IIB |
| Meyer22 | ABVD / yes | EF / no (n = 64) and yes (n = 139) | 399 / yes | |
| Author/Reference . | Chemotherapy/Efficacy Equivalence to ABVD . | Radiation Therapy/Part of Combined Modality Therapy . | Sample Size/Power to Detect Important Differences . | Other . |
|---|---|---|---|---|
| Abbreviations: MOPP, nitrogen mustard, Oncovin® (vincristine), prednisone, procarbazine; CVPP, cyclophosphamide, vinblastine, prednisone, procarbazine; EBVP, epirubicin, bleomycin, vinblastine, prednisone; COPP, cyclophosphamide, Oncovin® (vincristine), prednisone, procarbazine; ABVD, doxorubicin (Adriamycin®), bleomycin, vinblastine and dacarbazine; (S)TNI, (sub) total nodal irradiation; IF, involved field; EF, extended field | ||||
| Longo16 | MOPP / no | STNI or TNI / no | 106 / no | Includes Stages I–IIIA, I–IIB and patients with bulky disease |
| Biti17 | MOPP / no | EF / no | 99 / no | |
| Pavlovsky18 | CVPP / no | IF / yes | 277 / yes | Includes Stages I–IIA+B and patients with bulky disease |
| Noordijk14 | EBVP / no | IF / yes | 619 / yes | |
| Laskar19 | ABVD / yes | Predominantly IF / yes | 99 / no | Subset analysis |
| Nachman20 | COPP-ABV / yes | IF / yes | 215 / uncertain | Subset analysis; included pediatric patients only |
| Straus21 | ABVD / yes | EF (n = 54) and IF (n = 11) in an “as treated” analysis / yes | 152 / no | Includes Stages I–IIIA and I–IIB |
| Meyer22 | ABVD / yes | EF / no (n = 64) and yes (n = 139) | 399 / yes | |