Characteristics of the 5q– syndrome (according to Van den Berghe,1 subsequently restricted to cases with marrow blasts < 5% by the WHO classification3).
| Clinical and Biological Features |
| Female preponderance |
| Severe anemia |
| Pronounced macrocytosis |
| Normal or moderately decreased leucocytes |
| Normal or moderately increased platelets |
| Rare AML transformation (10%) |
| Prolonged survival |
| Bone Marrow Features |
| Characteristic dysmegakaryopoiesis (large monolobulated megakaryocytes with excentred nucleus) |
| No or moderate blast excess (restricted to marrow blasts < 5% in the WHO classification3) |
| Isolated 5q deletion |
| Clinical and Biological Features |
| Female preponderance |
| Severe anemia |
| Pronounced macrocytosis |
| Normal or moderately decreased leucocytes |
| Normal or moderately increased platelets |
| Rare AML transformation (10%) |
| Prolonged survival |
| Bone Marrow Features |
| Characteristic dysmegakaryopoiesis (large monolobulated megakaryocytes with excentred nucleus) |
| No or moderate blast excess (restricted to marrow blasts < 5% in the WHO classification3) |
| Isolated 5q deletion |