GVHD outcomes
| . | aGVHD 2-4 . | aGVHD 3-4 . | ||||||
|---|---|---|---|---|---|---|---|---|
| aGVHD variable . | n . | RR . | 99% CI . | P . | n . | RR . | 99% CI . | P . |
| Donor group (main effect) | ||||||||
| Parous sibling | 880 | 1.00 | 880 | 1.00 | ||||
| Male unrelated | 1908 | 1.56 | 1.31-1.85 | <.0001 | 1908 | 1.27 | 0.98-1.64 | .016 |
| GVHD prophylaxis | .002 | .0002 | ||||||
| Tac + MTX | 1094 | 1.00 | 1094 | 1.00 | ||||
| Tac + MTX + others | 202 | 1.12 | 0.65-1.18 | .258 | 202 | 1.12 | 0.72-1.74 | .502 |
| Tac ± others | 480 | 1.11 | 0.84-1.28 | .632 | 480 | 1.11 | 0.80-1.53 | .410 |
| CsA + MTX | 583 | 0.92 | 0.80-1.23 | .960 | 583 | 0.92 | 0.66-1.28 | .500 |
| CsA ± others | 315 | 1.75 | 1.09-1.72 | .0001 | 315 | 1.75 | 1.26-2.43 | <.0001 |
| Others | 112 | 1.20 | 0.91-1.86 | .062 | 112 | 1.20 | 0.69-2.10 | .389 |
| Graft source | ||||||||
| BM | 578 | 1.00 | – | – | – | – | ||
| PB | 2213 | 1.32 | 1.08-1.61 | .0003 | – | – | – | – |
| . | aGVHD 2-4 . | aGVHD 3-4 . | ||||||
|---|---|---|---|---|---|---|---|---|
| aGVHD variable . | n . | RR . | 99% CI . | P . | n . | RR . | 99% CI . | P . |
| Donor group (main effect) | ||||||||
| Parous sibling | 880 | 1.00 | 880 | 1.00 | ||||
| Male unrelated | 1908 | 1.56 | 1.31-1.85 | <.0001 | 1908 | 1.27 | 0.98-1.64 | .016 |
| GVHD prophylaxis | .002 | .0002 | ||||||
| Tac + MTX | 1094 | 1.00 | 1094 | 1.00 | ||||
| Tac + MTX + others | 202 | 1.12 | 0.65-1.18 | .258 | 202 | 1.12 | 0.72-1.74 | .502 |
| Tac ± others | 480 | 1.11 | 0.84-1.28 | .632 | 480 | 1.11 | 0.80-1.53 | .410 |
| CsA + MTX | 583 | 0.92 | 0.80-1.23 | .960 | 583 | 0.92 | 0.66-1.28 | .500 |
| CsA ± others | 315 | 1.75 | 1.09-1.72 | .0001 | 315 | 1.75 | 1.26-2.43 | <.0001 |
| Others | 112 | 1.20 | 0.91-1.86 | .062 | 112 | 1.20 | 0.69-2.10 | .389 |
| Graft source | ||||||||
| BM | 578 | 1.00 | – | – | – | – | ||
| PB | 2213 | 1.32 | 1.08-1.61 | .0003 | – | – | – | – |
| All donor/recipient pairs . | Male recipients only . | |||||||
|---|---|---|---|---|---|---|---|---|
| cGVHD variable . | n . | RR . | 99% CI . | P . | n . | RR . | 99% CI . | P . |
| Donor/recipient pair (main effect) | <.0001 | |||||||
| Parous sibling to female | 405 | 1.00 | ||||||
| Parous sibling to male | 474 | 1.39 | 1.09-1.78 | .001 | 474 | 1.00 | ||
| Male unrelated to female | 799 | 1.43 | 1.14-1.80 | <.0001 | ||||
| Male unrelated to male | 1099 | 1.52 | 1.22-1.89 | <.0001 | 1099 | 1.09 | 0.90-1.32 | .231 |
| Year of transplant | .002 | ns | ||||||
| 2000-2003 | 564 | 1.00 | ||||||
| 2004-2008 | 1471 | 1.06 | 0.88-1.29 | .381 | ||||
| 2009-2012 | 742 | 0.86 | 0.70-1.06 | .064 | ||||
| Graft source | ||||||||
| BM | 574 | 1 | 327 | 1.00 | ||||
| PB | 2203 | 1.73 | 1.43-2.08 | <.0001 | 1246 | 1.56 | 1.23-2.08 | <.0001 |
| All donor/recipient pairs . | Male recipients only . | |||||||
|---|---|---|---|---|---|---|---|---|
| cGVHD variable . | n . | RR . | 99% CI . | P . | n . | RR . | 99% CI . | P . |
| Donor/recipient pair (main effect) | <.0001 | |||||||
| Parous sibling to female | 405 | 1.00 | ||||||
| Parous sibling to male | 474 | 1.39 | 1.09-1.78 | .001 | 474 | 1.00 | ||
| Male unrelated to female | 799 | 1.43 | 1.14-1.80 | <.0001 | ||||
| Male unrelated to male | 1099 | 1.52 | 1.22-1.89 | <.0001 | 1099 | 1.09 | 0.90-1.32 | .231 |
| Year of transplant | .002 | ns | ||||||
| 2000-2003 | 564 | 1.00 | ||||||
| 2004-2008 | 1471 | 1.06 | 0.88-1.29 | .381 | ||||
| 2009-2012 | 742 | 0.86 | 0.70-1.06 | .064 | ||||
| Graft source | ||||||||
| BM | 574 | 1 | 327 | 1.00 | ||||
| PB | 2203 | 1.73 | 1.43-2.08 | <.0001 | 1246 | 1.56 | 1.23-2.08 | <.0001 |
CI, confidence interval; parous sibling, parous sibling donor; PB, peripheral blood; ns, not significant.