Table 1. Uni- and multivariate analyses... | American Society of Hematology

Table 1.

Uni- and multivariate analyses of the impact of viremia on T-cell reconstitution after HCT

	Univariate	Multivariate
Outcome	P	HR	95% CI	P
HHV6
CD3⁺ IR	<.001***	0.922	0.902-0.942	<.001***
CD4⁺ IR	<.001***	0.913	0.892-0.934	<.001***
CD8⁺ IR	<.001***	0.912	0.891-0.933	<.001***
EBV
CD3⁺ IR	.006**	0.963	0.937-0.991	.01*
CD4⁺ IR	.006**	0.964	0.937-0.993	.01*
CD8⁺ IR	.015*	0.962	0.934-0.989	.01*
CMV
CD3⁺ IR	.034*	0.971	0.882-1.068	.54
CD4⁺ IR	.033*	0.972	0.877-1.077	.58
CD8⁺ IR	.081	1.015	0.936-1.101	.71
AdV
CD3⁺ IR	.58	0.999	0.999-1.000	.55
CD4⁺ IR	.57	0.999	0.999-1.000	.58
CD8⁺ IR	.63	0.999	0.999-1.000	.64
Antiviral treatment
CD3⁺ IR	<.001***	1.566	1.459-1.681	<.001***
CD4⁺ IR	<.001***	1.572	1.463-1.690	<.001***
CD8⁺ IR	<.001***	1.707	1.586-1.837	<.001***

	Univariate	Multivariate
Outcome	P	HR	95% CI	P
HHV6
CD3⁺ IR	<.001***	0.922	0.902-0.942	<.001***
CD4⁺ IR	<.001***	0.913	0.892-0.934	<.001***
CD8⁺ IR	<.001***	0.912	0.891-0.933	<.001***
EBV
CD3⁺ IR	.006**	0.963	0.937-0.991	.01*
CD4⁺ IR	.006**	0.964	0.937-0.993	.01*
CD8⁺ IR	.015*	0.962	0.934-0.989	.01*
CMV
CD3⁺ IR	.034*	0.971	0.882-1.068	.54
CD4⁺ IR	.033*	0.972	0.877-1.077	.58
CD8⁺ IR	.081	1.015	0.936-1.101	.71
AdV
CD3⁺ IR	.58	0.999	0.999-1.000	.55
CD4⁺ IR	.57	0.999	0.999-1.000	.58
CD8⁺ IR	.63	0.999	0.999-1.000	.64
Antiviral treatment
CD3⁺ IR	<.001***	1.566	1.459-1.681	<.001***
CD4⁺ IR	<.001***	1.572	1.463-1.690	<.001***
CD8⁺ IR	<.001***	1.707	1.586-1.837	<.001***

Virus and cell recovery were considered time-varying variables. Analyses were corrected for variables other than viruses that are known to affect immune reconstitution (serotherapy, graft source, steroid-treated aGVHD, age). Cox proportional hazard models were used. Hazard ratio (HR) on T-cell reconstitution probability for every 10⁵ viral copies/mL plasma.

CI, confidence interval.

P < .05; **P < .01; ***P < .001.

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