Results of autologous hematopoietic stem cell transplantation according to country socioeconomic factors and transplant team density
| . | N . | RI, % (95% CI) . | NRM, % (95% CI) . | 100 d NRM, % (95% CI) . | PFS, % (95% CI) . | OS, % (95% CI) . |
|---|---|---|---|---|---|---|
| Multiple sclerosis | ||||||
| HDI | ||||||
| ≤Median | 503 | 35.4 (29.9-40.9) | 1.6 (0.7-3.2) | 1.6 (0.7-3.2) | 63 (57.4-68.6) | 95.4 (93.3-97.6) |
| >Median | 226 | 38.5 (29.5-47.3) | 0.5 (0-2.6) | 0.5 (0-2.6) | 61 (52.1-69.9) | 95.5 (91.8-99.3) |
| P | .98 | .55 | .55 | .87 | .27 | |
| HCE | ||||||
| ≤Median | 291 | 46.1 (38.3-53.6) | 2 (0.8-4.5) | 2.1 (0.8-4.5) | 51.8 (44.2-59.5) | 94.8 (91.7-97.9) |
| >Median | 205 | 37.9 (28.5-47.3) | 0 | 0 | 62.1 (52.6-71.6) | 95.5 (91.4-99.7) |
| P | .054 | .21 | .2 | .02 | .59 | |
| Team density | ||||||
| ≤Median | 465 | 42.6 (36.2-48.9) | 1 (0.3-2.4) | 1 (0.3-2.4) | 56.4 (50-62.8) | 96.4 (94.3-98.5) |
| >Median | 264 | 27.5 (21-34.4) | 1.8 (0.6-4.2) | 1.8 (0.6-4.2) | 70.7 (63.9-77.6) | 94.1 (90.8-97.5) |
| P | .002 | .63 | .66 | .004 | .24 | |
| Systemic sclerosis | ||||||
| HDI | ||||||
| ≤Median | 124 | 31 (21.6-40.8) | 10 (5-16.9) | 6.4 (2.8-12.1) | 59 (48.8-69.3) | 79.1 (70.7-87.5) |
| >Median | 209 | 31.1 (23.8-38.7) | 7 (3.9-11.2) | 5.2 (2.7-9) | 6 1.9 (54.1-69.7) | 81.1 (75.3-87) |
| P | .8 | .44 | .44 | .8 | .4 | |
| HCE | ||||||
| ≤Median | 117 | 37.3 (27.1-47.5) | 11.8 (6.4-19.1) | 8.4 (4.1-14.6) | 50.9 (40.3-61.5) | 75.2 (66.4-84) |
| >Median | 154 | 29.3 (20.9-38.1) | 5.8 (2.7-10.7) | 4.2 (1.7-8.5) | 64.9 (55.9-73.9) | 81.5 (74.6-88.5) |
| P | .71 | .02 | .02 | .07 | .01 | |
| Team density | ||||||
| ≤Median | 123 | 30.1 (20.8-40) | 9 (4.3-15.7) | 6.4 (2.8-12.1) | 60.9 (50.6-71.2) | 80.5 (72.3-88.6) |
| >Median | 210 | 31.6 (24.2-39.2) | 7.5 (4.3-11.9) | 5.2 (2.6-9) | 60.9 (53.1-68.7) | 80.4 (74.5-86.4) |
| P | .87 | .79 | .77 | .75 | .93 | |
| Crohn disease | ||||||
| HDI | ||||||
| ≤Median | 60 | 62.8 (45.4-76.1) | 1.7 (0.1-8.2) | 1.7 (0.1-8.2) | 35.5 (20.5-50.4) | 98.3 (95-100) |
| >Median | 41 | 56.5 (31.3-75.6) | 0 | 0 | 43.5 (21.7-65.4) | 97.5 (92.7-100) |
| P | .31 | .44 | .44 | .23 | .87 | |
| HCE | ||||||
| ≤Median | 46 | 60.5 (41-75.3) | 2.2 (0.2-10.1) | 2.2 (0.2-10.1) | 37.3 (20.6-54.1) | 97.8 (93.6-100) |
| >Median | 41 | 56.5 (31.3-75.6) | 0 | 0 | 43.5 (21.7-65.4) | 97.5 (92.7-100) |
| P | .45 | .38 | .38 | .33 | .9 | |
| Team density | ||||||
| ≤Median | 56 | 57.8 (40.5-71.8) | 1.8 (0.1-8.6) | 1.8 (0.1-8.6) | 40.3 (24.9-55.8) | 96.4 (91.6-100) |
| >Median | 45 | 65.6 (39.5-82.5) | 0 | 0 | 34.4 (13.8-55.1) | 100 (100-100) |
| P | .76 | .41 | .41 | .61 | .7 | |
| . | N . | RI, % (95% CI) . | NRM, % (95% CI) . | 100 d NRM, % (95% CI) . | PFS, % (95% CI) . | OS, % (95% CI) . |
|---|---|---|---|---|---|---|
| Multiple sclerosis | ||||||
| HDI | ||||||
| ≤Median | 503 | 35.4 (29.9-40.9) | 1.6 (0.7-3.2) | 1.6 (0.7-3.2) | 63 (57.4-68.6) | 95.4 (93.3-97.6) |
| >Median | 226 | 38.5 (29.5-47.3) | 0.5 (0-2.6) | 0.5 (0-2.6) | 61 (52.1-69.9) | 95.5 (91.8-99.3) |
| P | .98 | .55 | .55 | .87 | .27 | |
| HCE | ||||||
| ≤Median | 291 | 46.1 (38.3-53.6) | 2 (0.8-4.5) | 2.1 (0.8-4.5) | 51.8 (44.2-59.5) | 94.8 (91.7-97.9) |
| >Median | 205 | 37.9 (28.5-47.3) | 0 | 0 | 62.1 (52.6-71.6) | 95.5 (91.4-99.7) |
| P | .054 | .21 | .2 | .02 | .59 | |
| Team density | ||||||
| ≤Median | 465 | 42.6 (36.2-48.9) | 1 (0.3-2.4) | 1 (0.3-2.4) | 56.4 (50-62.8) | 96.4 (94.3-98.5) |
| >Median | 264 | 27.5 (21-34.4) | 1.8 (0.6-4.2) | 1.8 (0.6-4.2) | 70.7 (63.9-77.6) | 94.1 (90.8-97.5) |
| P | .002 | .63 | .66 | .004 | .24 | |
| Systemic sclerosis | ||||||
| HDI | ||||||
| ≤Median | 124 | 31 (21.6-40.8) | 10 (5-16.9) | 6.4 (2.8-12.1) | 59 (48.8-69.3) | 79.1 (70.7-87.5) |
| >Median | 209 | 31.1 (23.8-38.7) | 7 (3.9-11.2) | 5.2 (2.7-9) | 6 1.9 (54.1-69.7) | 81.1 (75.3-87) |
| P | .8 | .44 | .44 | .8 | .4 | |
| HCE | ||||||
| ≤Median | 117 | 37.3 (27.1-47.5) | 11.8 (6.4-19.1) | 8.4 (4.1-14.6) | 50.9 (40.3-61.5) | 75.2 (66.4-84) |
| >Median | 154 | 29.3 (20.9-38.1) | 5.8 (2.7-10.7) | 4.2 (1.7-8.5) | 64.9 (55.9-73.9) | 81.5 (74.6-88.5) |
| P | .71 | .02 | .02 | .07 | .01 | |
| Team density | ||||||
| ≤Median | 123 | 30.1 (20.8-40) | 9 (4.3-15.7) | 6.4 (2.8-12.1) | 60.9 (50.6-71.2) | 80.5 (72.3-88.6) |
| >Median | 210 | 31.6 (24.2-39.2) | 7.5 (4.3-11.9) | 5.2 (2.6-9) | 60.9 (53.1-68.7) | 80.4 (74.5-86.4) |
| P | .87 | .79 | .77 | .75 | .93 | |
| Crohn disease | ||||||
| HDI | ||||||
| ≤Median | 60 | 62.8 (45.4-76.1) | 1.7 (0.1-8.2) | 1.7 (0.1-8.2) | 35.5 (20.5-50.4) | 98.3 (95-100) |
| >Median | 41 | 56.5 (31.3-75.6) | 0 | 0 | 43.5 (21.7-65.4) | 97.5 (92.7-100) |
| P | .31 | .44 | .44 | .23 | .87 | |
| HCE | ||||||
| ≤Median | 46 | 60.5 (41-75.3) | 2.2 (0.2-10.1) | 2.2 (0.2-10.1) | 37.3 (20.6-54.1) | 97.8 (93.6-100) |
| >Median | 41 | 56.5 (31.3-75.6) | 0 | 0 | 43.5 (21.7-65.4) | 97.5 (92.7-100) |
| P | .45 | .38 | .38 | .33 | .9 | |
| Team density | ||||||
| ≤Median | 56 | 57.8 (40.5-71.8) | 1.8 (0.1-8.6) | 1.8 (0.1-8.6) | 40.3 (24.9-55.8) | 96.4 (91.6-100) |
| >Median | 45 | 65.6 (39.5-82.5) | 0 | 0 | 34.4 (13.8-55.1) | 100 (100-100) |
| P | .76 | .41 | .41 | .61 | .7 | |