Significant canonical pathways in naive cord blood CD4+ T cells after enrichment mapping (at P < .005; FDR q value < 0.1) of gene set enrichment analysis pathways
| Name . | Size . | ES . | NES . | NOM P value . | FDR q value . |
|---|---|---|---|---|---|
| BIOCARTA_STRESS_PATHWAY | 25 | 0.747852 | 2.153037 | 0 | 0.002696 |
| BIOCARTA_TNFR2_PATHWAY | 18 | 0.747083 | 2.006501 | 0 | 0.005757 |
| BIOCARTA_GPCR_PATHWAY | 32 | 0.649287 | 1.973769 | 0 | 0.008621 |
| KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 107 | 0.511906 | 1.956901 | 0 | 0.009042 |
| BIOCARTA_MET_PATHWAY | 35 | 0.63085 | 1.940215 | 0 | 0.010134 |
| BIOCARTA_TCR_PATHWAY | 42 | 0.590207 | 1.891878 | 0 | 0.014213 |
| BIOCARTA_MAPK_PATHWAY | 86 | 0.490017 | 1.785455 | 0 | 0.023409 |
| KEGG_MAPK_SIGNALING_PATHWAY | 257 | 0.363248 | 1.548704 | .0015873 | 0.096791 |
| BIOCARTA_PPARA_PATHWAY | 54 | 0.507107 | 1.717286 | .00174216 | 0.037614 |
| BIOCARTA_PYK2_PATHWAY | 26 | 0.635627 | 1.843618 | .00174825 | 0.019434 |
| BIOCARTA_INTEGRIN_PATHWAY | 35 | 0.568651 | 1.794564 | .00190476 | 0.023841 |
| BIOCARTA_HSP27_PATHWAY | 15 | 0.698828 | 1.79994 | .00195313 | 0.023302 |
| BIOCARTA_CDMAC_PATHWAY | 16 | 0.768664 | 1.966973 | .00199601 | 0.008 |
| BIOCARTA_INSULIN_PATHWAY | 21 | 0.67222 | 1.866742 | .00205339 | 0.018618 |
| BIOCARTA_IL1R_PATHWAY | 33 | 0.582227 | 1.803144 | .00361664 | 0.024056 |
| BIOCARTA_IGF1_PATHWAY | 21 | 0.648103 | 1.779082 | .00365631 | 0.024106 |
| BIOCARTA_RELA_PATHWAY | 16 | 0.715302 | 1.845727 | .0037594 | 0.020061 |
| BIOCARTA_RACCYCD_PATHWAY | 26 | 0.628528 | 1.833218 | .003861 | 0.02129 |
| BIOCARTA_IL6_PATHWAY | 22 | 0.684749 | 1.897918 | .00391389 | 0.013879 |
| Name . | Size . | ES . | NES . | NOM P value . | FDR q value . |
|---|---|---|---|---|---|
| BIOCARTA_STRESS_PATHWAY | 25 | 0.747852 | 2.153037 | 0 | 0.002696 |
| BIOCARTA_TNFR2_PATHWAY | 18 | 0.747083 | 2.006501 | 0 | 0.005757 |
| BIOCARTA_GPCR_PATHWAY | 32 | 0.649287 | 1.973769 | 0 | 0.008621 |
| KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 107 | 0.511906 | 1.956901 | 0 | 0.009042 |
| BIOCARTA_MET_PATHWAY | 35 | 0.63085 | 1.940215 | 0 | 0.010134 |
| BIOCARTA_TCR_PATHWAY | 42 | 0.590207 | 1.891878 | 0 | 0.014213 |
| BIOCARTA_MAPK_PATHWAY | 86 | 0.490017 | 1.785455 | 0 | 0.023409 |
| KEGG_MAPK_SIGNALING_PATHWAY | 257 | 0.363248 | 1.548704 | .0015873 | 0.096791 |
| BIOCARTA_PPARA_PATHWAY | 54 | 0.507107 | 1.717286 | .00174216 | 0.037614 |
| BIOCARTA_PYK2_PATHWAY | 26 | 0.635627 | 1.843618 | .00174825 | 0.019434 |
| BIOCARTA_INTEGRIN_PATHWAY | 35 | 0.568651 | 1.794564 | .00190476 | 0.023841 |
| BIOCARTA_HSP27_PATHWAY | 15 | 0.698828 | 1.79994 | .00195313 | 0.023302 |
| BIOCARTA_CDMAC_PATHWAY | 16 | 0.768664 | 1.966973 | .00199601 | 0.008 |
| BIOCARTA_INSULIN_PATHWAY | 21 | 0.67222 | 1.866742 | .00205339 | 0.018618 |
| BIOCARTA_IL1R_PATHWAY | 33 | 0.582227 | 1.803144 | .00361664 | 0.024056 |
| BIOCARTA_IGF1_PATHWAY | 21 | 0.648103 | 1.779082 | .00365631 | 0.024106 |
| BIOCARTA_RELA_PATHWAY | 16 | 0.715302 | 1.845727 | .0037594 | 0.020061 |
| BIOCARTA_RACCYCD_PATHWAY | 26 | 0.628528 | 1.833218 | .003861 | 0.02129 |
| BIOCARTA_IL6_PATHWAY | 22 | 0.684749 | 1.897918 | .00391389 | 0.013879 |
Bold text indicates pathways that are discussed in the “Results” and “Discussion.”
ES, enrichment score; FDR, false discovery rate; NES, normalized enrichment score; NOM, nominal.