Table 1.

Target proteins measured by MRM and their corresponding surrogate peptides

ProteinMRM peptideCorrelation between activity/antibody assay and MRM measurements
Regression slopePearson correlationR2R2 95% confidence interval
α-2 antiplasmin LGNQEPGGQTALK 0.68 0.68 0.46 0.3-0.62 
DFLQSLK 0.68 0.68 0.46 0.31-0.63 
Antithrombin-III DDLYVSDAFHK 0.60 0.67 0.45 0.25-0.66 
TSDQIHFFFAK 0.71 0.71 0.50 0.28-0.69 
FATTFYQHLADSK 0.62 0.62 0.38 0.2-0.6 
Coagulation factor IX IIPHHNYNAAINK 0.75 0.75 0.56 0.41-0.71 
SALVLQYLR 0.74 0.74 0.55 0.4-0.71 
VSVSQTSK 0.46 0.46 0.21 0.06-0.37 
Coagulation factor V GEYEEHLGILGPIIR 0.80 0.80 0.64 0.5-0.77 
AEVDDVIQVR 0.89 0.89 0.80 0.68-0.88 
SQHLDNFSNQIGK 0.86 0.86 0.74 0.61-0.86 
Coagulation factor VII VAQVIIPSTYVPGTTNHDIALLR 0.85 0.78 0.61 0.39-0.77 
Coagulation factor X ETYDFDIAVLR 1.08 0.74 0.55 0.4-0.68 
GYTLADNGK 1.24 0.86 0.73 0.66-0.84 
TGIVSGFGR 1.26 0.90 0.81 0.73-0.9 
Coagulation factor XI TSESGLPSTR 0.85 0.85 0.73 0.61-0.82 
Fibrinogen α chain ESSSHHPGIAEFPSR 0.68 0.68 0.46 0.25-0.65 
VQHIQLLQK 0.74 0.76 0.58 0.44-0.73 
GSESGIFTNTK 0.72 0.72 0.52 0.29-0.71 
Fibrinogen β chain AHYGGFTVQNEANK 0.79 0.79 0.62 0.43-0.77 
HQLYIDETVNSNIPTNLR 0.79 0.79 0.63 0.46-0.76 
YQISVNK 0.71 0.75 0.57 0.4-0.72 
Fibrinogen γ chain IHLISTQSAIPYALR 0.68 0.74 0.55 0.37-0.7 
YLQEIYNSNNQK 0.76 0.76 0.58 0.38-0.74 
YEASILTHDSSIR 0.80 0.80 0.64 0.47-0.78 
Plasminogen LFLEPTR 0.77 0.93 0.86 0.79-0.91 
Prothrombin ELLESYIDGR 1.34 0.87 0.76 0.64-0.85 
ETAASLLQAGYK 1.15 0.78 0.61 0.46-0.76 
TATSEYQTFFNPR 1.23 0.85 0.72 0.54-0.85 
Vitamin K–dependent protein C DTEDQEDQVDPR 0.88 0.88 0.77 0.66-0.87 
LGEYDLR 0.89 0.90 0.80 0.72-0.87 
TFVLNFIK 0.92 0.92 0.84 0.75-0.91 
Vitamin K–dependent protein S IETISHEDLQR 0.88 0.88 0.77 0.66-0.86 
SFQTGLFTAAR 0.86 0.86 0.74 0.6-0.85 
VYFAGFPR 0.90 0.90 0.81 0.69-0.89 
VWF ILAGPAGDSNVVK 0.11 0.18 0.03 0-0.26 
ProteinMRM peptideCorrelation between activity/antibody assay and MRM measurements
Regression slopePearson correlationR2R2 95% confidence interval
α-2 antiplasmin LGNQEPGGQTALK 0.68 0.68 0.46 0.3-0.62 
DFLQSLK 0.68 0.68 0.46 0.31-0.63 
Antithrombin-III DDLYVSDAFHK 0.60 0.67 0.45 0.25-0.66 
TSDQIHFFFAK 0.71 0.71 0.50 0.28-0.69 
FATTFYQHLADSK 0.62 0.62 0.38 0.2-0.6 
Coagulation factor IX IIPHHNYNAAINK 0.75 0.75 0.56 0.41-0.71 
SALVLQYLR 0.74 0.74 0.55 0.4-0.71 
VSVSQTSK 0.46 0.46 0.21 0.06-0.37 
Coagulation factor V GEYEEHLGILGPIIR 0.80 0.80 0.64 0.5-0.77 
AEVDDVIQVR 0.89 0.89 0.80 0.68-0.88 
SQHLDNFSNQIGK 0.86 0.86 0.74 0.61-0.86 
Coagulation factor VII VAQVIIPSTYVPGTTNHDIALLR 0.85 0.78 0.61 0.39-0.77 
Coagulation factor X ETYDFDIAVLR 1.08 0.74 0.55 0.4-0.68 
GYTLADNGK 1.24 0.86 0.73 0.66-0.84 
TGIVSGFGR 1.26 0.90 0.81 0.73-0.9 
Coagulation factor XI TSESGLPSTR 0.85 0.85 0.73 0.61-0.82 
Fibrinogen α chain ESSSHHPGIAEFPSR 0.68 0.68 0.46 0.25-0.65 
VQHIQLLQK 0.74 0.76 0.58 0.44-0.73 
GSESGIFTNTK 0.72 0.72 0.52 0.29-0.71 
Fibrinogen β chain AHYGGFTVQNEANK 0.79 0.79 0.62 0.43-0.77 
HQLYIDETVNSNIPTNLR 0.79 0.79 0.63 0.46-0.76 
YQISVNK 0.71 0.75 0.57 0.4-0.72 
Fibrinogen γ chain IHLISTQSAIPYALR 0.68 0.74 0.55 0.37-0.7 
YLQEIYNSNNQK 0.76 0.76 0.58 0.38-0.74 
YEASILTHDSSIR 0.80 0.80 0.64 0.47-0.78 
Plasminogen LFLEPTR 0.77 0.93 0.86 0.79-0.91 
Prothrombin ELLESYIDGR 1.34 0.87 0.76 0.64-0.85 
ETAASLLQAGYK 1.15 0.78 0.61 0.46-0.76 
TATSEYQTFFNPR 1.23 0.85 0.72 0.54-0.85 
Vitamin K–dependent protein C DTEDQEDQVDPR 0.88 0.88 0.77 0.66-0.87 
LGEYDLR 0.89 0.90 0.80 0.72-0.87 
TFVLNFIK 0.92 0.92 0.84 0.75-0.91 
Vitamin K–dependent protein S IETISHEDLQR 0.88 0.88 0.77 0.66-0.86 
SFQTGLFTAAR 0.86 0.86 0.74 0.6-0.85 
VYFAGFPR 0.90 0.90 0.81 0.69-0.89 
VWF ILAGPAGDSNVVK 0.11 0.18 0.03 0-0.26 
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